Is dantrolene used to treat malignant hyperthermia?
In this regard, how does dantrolene treat malignant hyperthermia?
Dantrolene is the only currently accepted specific treatment for MH. In an episode of MH, muscle metabolism is dramatically increased secondary to an increase in calcium within the muscle. This causes muscles to contract, ATP hydrolysis, and heat production.
Also, what drug class is dantrolene? Dantrolene is classified as a direct-acting skeletal muscle relaxant. It is currently the only specific and effective treatment for malignant hyperthermia.
Thereof, what drugs are used to treat malignant hyperthermia?
As soon as malignant hyperthermia is suspected, doctors must act rapidly to treat the condition and prevent complications. The first and most important step is to immediately stop giving the triggering medication and to stop the surgery. Doctors then give the drug dantrolene (Dantrium). Dantrolene relaxes the muscles.
How do you give dantrolene?
Administer dantrolene suspension intravenously over at least 1 minute when using for prevention of malignant hyperthermia. Inject into the intravenous catheter while an IV infusion of 0.9% Sodium Chloride injection or 5% Dextrose injection is freely running.