How does dantrolene reverse hyperthermia?
Simply so, why dantrolene is used in malignant hyperthermia?
Dantrolene sodium uncouples the heat-generating mechanism in muscle and is the drug of choice in treating malignant hyperthermia and neuroleptic malignant syndrome, which cause excessive muscular heat production. The potential benefit of this drug in treating heat stroke has been debated.
Subsequently, question is, what is dantrolene an antidote for? Dantrolene produces relaxation of skeletal muscle without causing complete paralysis, and is the only xenobiotic proven to be effective for both treatment and prophylaxis of malignant hyperthermia (MH).
In this manner, what is the mechanism of action of dantrolene?
Mechanism of action Dantrolene depresses excitation-contraction coupling in skeletal muscle by acting as a receptor antagonist to the ryanodine receptor, and decreasing free intracellular calcium concentration.
What is the antidote for malignant hyperthermia?