How does dantrolene reverse hyperthermia?
Simply so, why dantrolene is used in malignant hyperthermia?
Dantrolene sodium uncouples the heat-generating mechanism in muscle and is the drug of choice in treating malignant hyperthermia and neuroleptic malignant syndrome, which cause excessive muscular heat production. The potential benefit of this drug in treating heat stroke has been debated.
In this manner, what is the mechanism of action of dantrolene?
Mechanism of action Dantrolene depresses excitation-contraction coupling in skeletal muscle by acting as a receptor antagonist to the ryanodine receptor, and decreasing free intracellular calcium concentration.