How does dantrolene reverse hyperthermia?

Asked By: Abderrazzak Chetlapalli | Last Updated: 5th June, 2020
Category: medical health cancer
4.3/5 (57 Views . 44 Votes)
Dantrolene is the only currently accepted specific treatment for MH. In an episode of MH, muscle metabolism is dramatically increased secondary to an increase in calcium within the muscle. This causes muscles to contract, ATP hydrolysis, and heat production.

Click to see full answer


Simply so, why dantrolene is used in malignant hyperthermia?

Dantrolene sodium uncouples the heat-generating mechanism in muscle and is the drug of choice in treating malignant hyperthermia and neuroleptic malignant syndrome, which cause excessive muscular heat production. The potential benefit of this drug in treating heat stroke has been debated.

Subsequently, question is, what is dantrolene an antidote for? Dantrolene produces relaxation of skeletal muscle without causing complete paralysis, and is the only xenobiotic proven to be effective for both treatment and prophylaxis of malignant hyperthermia (MH).

In this manner, what is the mechanism of action of dantrolene?

Mechanism of action Dantrolene depresses excitation-contraction coupling in skeletal muscle by acting as a receptor antagonist to the ryanodine receptor, and decreasing free intracellular calcium concentration.

What is the antidote for malignant hyperthermia?

dantrolene

39 Related Question Answers Found

What type of drug is dantrolene?

Dantrolene is classified as a direct-acting skeletal muscle relaxant. It is currently the only specific and effective treatment for malignant hyperthermia.

How long do you give dantrolene?

Once the initial reaction is controlled, continued monitoring in the intensive care unit (ICU) for 24-48 hours is recommended, along with administration of dantrolene (1 mg/kg every 4-6 hours, or an equivalent amount given as a continuous infusion).

What is another name for dantrolene?

BRAND NAME(S): Dantrium. WARNING: Infrequently, dantrolene may cause very serious (possibly fatal) liver problems.

What are the side effects of dantrolene?

Common side effects of Dantrium Intravenous include:
  • muscle weakness,
  • drowsiness,
  • dizziness,
  • low energy,
  • tired feeling,
  • injection site reactions (pain, redness, or swelling),
  • diarrhea,
  • constipation,

How do you cool a patient with malignant hyperthermia?


Noninvasive treatments of hyperthermia include strategic ice packing, forced air cooling, circulating cool water blankets, cold intravenous fluids, and ice-water immersion.

How does dantrolene affect temperature?

Dantrolene is used for treatment of life-threatening hyperthermia, yet its thermoregulatory effects are unknown. We tested the hypothesis that dantrolene reduces the threshold (triggering core temperature) and gain (incremental increase) of shivering. The gain of shivering was the slope of oxygen consumption vs.

How do you prepare anesthesia for malignant hyperthermia?

Anaesthetic machines are prepared for use with patients who are susceptible to malignant hyperpyrexia (MH) by flushing with oxygen at 10 l/min for ten minutes to reduce the anaesthetic concentration to 1 part per million (ppm) or less.

Is dantrolene a controlled substance?

Dantrolene is used in the treatment of malignant hyperthermia; chronic spasticity and belongs to the drug class skeletal muscle relaxants. Dantrolene 50 mg is not a controlled substance under the Controlled Substances Act (CSA).

How does dantrolene help cerebral palsy?

Dantrolene (Dantrium) prevents full muscle contraction and therefore spasticity by inhibiting the release of calcium from the sarcoplasmic reticulum of skeletal muscle cells. Clinical trials determined that dantrolene is superior to placebo in the treatment of children with spasticity due to cerebral palsy.

What does dantrolene do?


Dantrolene helps reduce muscle pain and stiffness, improves your ability to move around, and lets you do more of your daily activities. Dantrolene is also used with other treatments to prevent or treat special cases of high fever (malignant hyperthermia) related to anesthesia and surgery.

How is dantrolene administered?

Dantrium Intravenous should be administered by continuous rapid intravenous push beginning at a minimum dose of 1 mg/kg, and continuing until symptoms subside or the maximum cumulative dose of 10 mg/kg has been reached.

How does the muscle relaxant drug dantrolene prevent the effects of MH?

Dantrolene is the only currently accepted specific treatment for MH. Dantrolene directly interferes with muscle contraction; decreasing calcium in muscle cells. Dantrolene does not block neuromuscular transmission nor interfere with reversal of muscle relaxants.

What medication is used for malignant hyperthermia?

As soon as malignant hyperthermia is suspected, doctors must act rapidly to treat the condition and prevent complications. The first and most important step is to immediately stop giving the triggering medication and to stop the surgery. Doctors then give the drug dantrolene (Dantrium). Dantrolene relaxes the muscles.

Which muscle relaxer is the strongest?

Which Muscle Relaxants Are Best for Neck and Back Pain?
  • 1) Methocarbamol. Methocarbamol (Robaxin) is a well-studied medication that treats back pain.
  • 2) Cyclobenzaprine.
  • 3) Carisoprodol.
  • 4) Metaxalone.
  • 5) Tizanidine.
  • 6) Baclofen.
  • 7) Oxazepam and diazepam.

Is dantrolene a calcium channel blocker?


Due to its ability to reduce intracellular calcium levels, dantrolene is a specific and effective agent in the treatment of malignant hyperthermia. Verapamil, a calcium channel blocker, has the ability to decrease calcium influx and can interact with dantrolene to produce hyperkalemia and myocardial depression.

How does dantrolene prevent muscle spasms?

Dantrolene works by stopping some electrical impulses travelling within muscles, thereby preventing muscle contractions. This contrasts with most other spasticity drugs that work by preventing or inhibiting the way the brain and spinal cord communicate through the nerves with the rest of the body.

What is neuroleptic malignant syndrome?

Neuroleptic malignant syndrome (NMS) is a rare reaction to antipsychotic drugs that treat schizophrenia, bipolar disorder, and other mental health conditions. It affects the nervous system and causes symptoms like a high fever and muscle stiffness.