How long is dantrolene given?

Asked By: Nausica Leible | Last Updated: 20th May, 2020
Category: medical health cancer
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Dantrium Intravenous: The recommended prophylactic dose of Dantrium Intravenous is 2.5 mg/kg, starting approximately 1-1/4 hours before anticipated anesthesia and infused over approximately 1 hour.

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Keeping this in view, how much is a vial of dantrolene?

We estimated that a vial of dantrolene costs $84. With a shelf-life of three years, this means that the annualized cost of stocking an MH cart with dantrolene is $1,008 ($84 per vial multiplied by 36 vials, divided by the shelf-life of three years).

Also, what schedule drug is dantrolene? Dantrolene is used in the treatment of malignant hyperthermia; chronic spasticity and belongs to the drug class skeletal muscle relaxants. Risk cannot be ruled out during pregnancy. Dantrolene 50 mg is not a controlled substance under the Controlled Substances Act (CSA).

One may also ask, what are the chances of recrudescence of MH after initial treatment with dantrolene?

Recrudescence of MH occurred in 20% of 308 patients examined. Half of the patients showed signs or symptoms of recrudescence within 9 h of the initial event (median time 8.7 h), and 80% did so within 16 h. Signs included muscle rigidity, evidence of increasing rhabdomyolysis, respiratory acidosis, and hyperthermia.

How does dantrolene treat malignant hyperthermia?

Dantrolene is the only currently accepted specific treatment for MH. In an episode of MH, muscle metabolism is dramatically increased secondary to an increase in calcium within the muscle. This causes muscles to contract, ATP hydrolysis, and heat production.

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How is dantrolene administered?

Dantrium Intravenous should be administered by continuous rapid intravenous push beginning at a minimum dose of 1 mg/kg, and continuing until symptoms subside or the maximum cumulative dose of 10 mg/kg has been reached.

How much does Ryanodex cost?

While Ryanodex provides more convenience, it costs more than twice as much — about $7,000 for three vials — and has a shorter half-life (two years) than do Dantrium and Revonto, which have a three-year shelf life.

What do you mix dantrolene with?


Each vial of dantrolene sodium for injection should be reconstituted by adding 60 mL of sterile water for injection USP (without a bacteriostatic agent), and the vial shaken for approximately 20 seconds or until the solution is clear.

What is malignant hyperthermia?

Malignant hyperthermia (MH) is a disease that causes a fast rise in body temperature and severe muscle contractions when someone with MH gets general anesthesia. MH is passed down through families. Hyperthermia means high body temperature.

What drugs are used to treat malignant hyperthermia?

As soon as malignant hyperthermia is suspected, doctors must act rapidly to treat the condition and prevent complications. The first and most important step is to immediately stop giving the triggering medication and to stop the surgery. Doctors then give the drug dantrolene (Dantrium). Dantrolene relaxes the muscles.

What is the first sign of malignant hyperthermia?

Early clinical signs of MH include an increase in end-tidal carbon dioxide (even with increasing minute ventilation), tachycardia, muscle rigidity, tachypnea, and hyperkalemia. Later signs include fever, myoglobinuria, and multiple organ failure. Anesthetics are inconsistent in triggering MH.

How do you flush anesthesia for malignant hyperthermia?

Anaesthetic machines are prepared for use with patients who are susceptible to malignant hyperpyrexia (MH) by flushing with oxygen at 10 l/min for ten minutes to reduce the anaesthetic concentration to 1 part per million (ppm) or less.

How do you cool a patient with malignant hyperthermia?


Noninvasive treatments of hyperthermia include strategic ice packing, forced air cooling, circulating cool water blankets, cold intravenous fluids, and ice-water immersion.

What should be in a malignant hyperthermia cart?

There are 3 grams of mannitol in each vial of 20 mg of dantrolene (0.15 g mannitol/ 1 mg dantrolene). RYANODEX® – 3 vials should be available in each institution where MH can occur, each to be diluted at the time of use with 5 ml of sterile water for injection, USP (without a bacteriostatic agent).

What is MH crisis?

Malignant hyperthermia (MH) is a rare but potentially deadly hypermetabolic crisis that typically occurs as a complication of general anesthesia.¹ The signs, which may arise at any time during anesthesia or the early postoperative period, result from hypermetabolism in skeletal muscle, probably as a result of

How long after anesthesia can malignant hyperthermia occur?

, malignant hyperthermia typically occurs shortly after anesthesia is first given. But it can occur at any time during anesthesia or in rare cases may occur as late as 24 hours after surgery. Malignant hyperthermia is very rare.

How can Malignant Hyperthermia be prevented?


Malignant hyperthermia can be prevented by avoiding the agents that bring it about: succinylcholine (Anectine®) and inhalational agents. Alternatives are readily available and can be substituted easily.

What is dantrolene the antidote for?

Dantrolene produces relaxation of skeletal muscle without causing complete paralysis, and is the only xenobiotic proven to be effective for both treatment and prophylaxis of malignant hyperthermia (MH).

What does dantrolene treat?

Dantrolene is also used to treat or prevent muscle stiffness and spasms caused by malignant hyperthermia (a rapid rise in body temperature and severe muscle contractions) that can occur during surgery with certain types of anesthesia. Dantrolene may also be used for purposes not listed in this medication guide.