What foods are high in trimethylamine?

Asked By: Karolina Rebani | Last Updated: 3rd March, 2020
Category: medical health infectious diseases
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Trimethylamine is present in high levels in milk obtained from wheat-fed cows. Choline is present in high amounts in: eggs, liver, kidney, peas, beans, peanuts, soy products, brussels sprouts, broccoli, cabbage, and cauliflower.

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Also know, what foods should be avoided with Trimethylaminuria?

Foods to avoid

  • cows' milk.
  • seafood and shellfish – freshwater fish is fine.
  • eggs.
  • beans.
  • peanuts.
  • liver and kidney.
  • supplements containing lecithin.

Beside above, what causes high Tmao? TMAO is formed after you eat foods containing a substance called choline, which is a nutrient found not only in red meat, but also eggs, fish, and poultry. As bacteria in your gut feast on the choline, they produce a substance called trimethylamine (TMA). Your liver takes that TMA and converts it into TMAO.

Thereof, how do I reduce trimethylamine?

Taking low doses of antibiotics to reduce the amount of bacteria in the gut. This suppresses the production of trimethylamine. Taking laxatives can decrease intestinal transit time and reduce the amount of trimethylamine produced in the gut.

Is Trimethylaminuria dangerous?

Because many patients have associated body odours or halitosis, trimethylaminuria sufferers can meet serious difficulties in a social context, leading to other problems such as isolation and depression.

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How do I know if I have Trimethylaminuria?

Symptoms. Trimethylaminuria is characterized primarily by a fishy odor that occurs when excess trimethylamine is released in the person's sweat, urine, reproductive fluids, and breath. Although some affected people may have a constant strong odor, most have a moderate odor that can vary in intensity.

How common is Trimethylaminuria?

Trimethylaminuria is a rare metabolic disorder. More than 100 cases have been reported in the medical literature. Some clinicians believe that the disorder is under-diagnosed since many people with mild symptoms do not seek help.

Why do I smell like poop?

Sinus and respiratory infections can cause your breath to smell like feces. These can be caused by bronchitis, viral colds, strep throat, and more. When bacteria move from your nose into your throat, it can cause your breath to have an incredibly unpleasant odor.

Why do I smell like poop after I poop?

Foul-smelling stools have an unusually strong, putrid smell. In many cases, foul-smelling stools occur due to the foods people eat and the bacteria present in their colon. However, foul-smelling stools can also indicate a serious health problem. Diarrhea, bloating, or flatulence may occur with foul-smelling stools.

Why does my body smell like urine?


As excess trimethylamine is released in a person's sweat, urine, and breath, it causes the odor characteristic of trimethylaminuria. The strong body odor may result from an excess of certain proteins in the diet or from an abnormal increase in bacteria that produce trimethylamine in the digestive system.

Can you smell yourself if you have TMAU?

Those who have TMAU are plagued by extreme body odor: Their urine, breath, and sweat are laced with a thick scent akin to that of rotting eggs, garbage, or stale fish, and it's completely impossible to control with bathing, deodorant, or other forms of personal hygiene.

Do guys smell down there?

It isn't unusual for your penis to have an odor. But if you feel like the scent has changed or grown stronger, it may be a sign of an underlying condition. Most conditions aren't serious and can be easily treated. For example, men who are uncircumcised may develop skin cell buildup underneath their foreskin.

What is trimethylamine used for?

Applications. Trimethylamine is used in the synthesis of choline, tetramethylammonium hydroxide, plant growth regulators or herbicides, strongly basic anion exchange resins, dye leveling agents and a number of basic dyes. Gas sensors to test for fish freshness detect trimethylamine.

Is choline bad for your heart?

Can choline be harmful? Getting too much choline can cause a fishy body odor, vomiting, heavy sweating and salivation, low blood pressure, and liver damage. Some research also suggests that high amounts of choline may increase the risk of heart disease. The daily upper limits for choline are listed below.

Can secondary TMAU be cured?


TMAU2 can in fact be cured by eradication of the excess bacteria, although stubborn colonies may regrow to excess and require further courses of treatment. TMAU1, as a genetic defect, cannot be completely cured although therapy (dietary and antibiotic) can successfully control the patient's TMA to a less odorous level.

How much choline is in red meat?

Sources of Choline
Food Milligrams (mg) per serving Percent DV*
Beef, ground, 93% lean meat, broiled, 3 ounces 72 13
Fish, cod, Atlantic, cooked, dry heat, 3 ounces 71 13
Mushrooms, shiitake, cooked, ½ cup pieces 58 11
Potatoes, red, baked, flesh and skin, 1 large potato 57 10

What foods contain choline?

Food sources
Eggs, liver, and peanuts, are especially rich in choline (27). Major contributors to choline in the American diet are meat, poultry, fish, dairy foods, pasta, rice, and egg-based dishes (77). Spinach, beets, wheat, and shellfish are also good sources of the choline metabolite, betaine (78).

What are normal Tmao levels?

Normal TMAO blood levels ranged 0.5–5 µM [7,15] and increased TMAO serum levels are associated with a greater CVD risk [1].

Where can I get tested for TMAU?

We now coordinate diagnostic testing for TMAU through the Biochemical Genetics Laboratory at Children's Hospital Colorado. We have decided that all testing will be coordinated through Monell so that the protocol using the Choline Challenge Test, developed over the past 25-plus years, remains consistent.

What is Trimethylaminuria TMAU disorder?


Trimethylaminuria (TMAU), also known as fish odor syndrome or fish malodor syndrome, is a rare metabolic disorder that causes a defect in the normal production of an enzyme named flavin-containing monooxygenase 3 (FMO3).

What is Tmao in fish?

Trimethylamine oxide (TMAO) is a common and compatible osmolyte in muscle tissues of marine organisms that is often credited with counteracting protein-destabilizing forces. However, the origin and synthetic pathways of TMAO are actively debated.

How does red meat cause heart disease?

High saturated fat levels in red meat have long been known to contribute to heart disease, the leading cause of death in the United States. The exact mechanisms by which TMAO may affect heart disease is complex. Prior research has shown that TMAO enhances cholesterol deposits in the artery wall.