What does it mean if Kappa Lambda ratio is high?
Also question is, does high kappa light chain mean myeloma?
In myeloma, all the abnormal plasma cells make the same antibody. Therefore, the myeloma can be classified by the type of light and heavy chains produced, such as IgG kappa, IgG lambda, IgA kappa, or IgA lambda, etc. The most common type of heavy chain produced in myeloma is IgG, followed by IgA and then IgD.
Beside above, what does high free kappa light chains mean? Increased kappa free light chains and an increased kappa/lambda ratio may be seen with plasma cell disorders that produce excess monoclonal kappa light chains. Monoclonal gammopathy of undetermined significance (MGUS) is the most common plasma cell disorder and it usually does not cause symptoms.
Keeping this in consideration, what is the normal kappa to lambda ratio?
The exact normal ratio of kappa to lambda, according to a novel polyclonal free light chain assay, ranges from 0.26 to 1.65. Both the kappa and the lambda chains can increase proportionately, maintaining a normal ratio. This is usually indicative of something other than a blood cell dyscrasia, such as kidney disease.
Which is worse kappa or lambda?
Patients with lambda light chain disease have a three times worse prognosis than kappa light chain disease. We report a case of lambda light chain deposition disease in a 35-year-old female who presented with acute renal failure requiring hemodialysis.