What causes TMAU?

Asked By: Alena Lazzaro | Last Updated: 13th January, 2020
Category: medical health infectious diseases
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Cause. Most cases of trimethylaminuria are caused by changes ( mutations ) in the FMO3 gene . This gene provides the body with instructions to make an enzyme that is responsible for breaking down certain nitrogen-containing compounds such as trimethylamine.

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In this regard, can you develop TMAU?

Some sufferers are born with the genetic mutation that causes TMAU, but others acquire it in adulthood (hormonal changes or chronic illness are two possible triggers).

Similarly, can you smell yourself if you have TMAU? Those who have TMAU are plagued by extreme body odor: Their urine, breath, and sweat are laced with a thick scent akin to that of rotting eggs, garbage, or stale fish, and it's completely impossible to control with bathing, deodorant, or other forms of personal hygiene.

Also Know, what causes fish odor syndrome?

Fish odor syndrome is characterized by an offensive body odor and the smell of rotting fish due to the excessive excretion of trimethylaminuria (TMA) in the urine, sweat, and breath of affected individuals. Fish odor syndrome is caused by mutations in the FMO3 gene.

Can secondary TMAU be cured?

TMAU2 can in fact be cured by eradication of the excess bacteria, although stubborn colonies may regrow to excess and require further courses of treatment. TMAU1, as a genetic defect, cannot be completely cured although therapy (dietary and antibiotic) can successfully control the patient's TMA to a less odorous level.

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How do I know if I have TMAU?

Symptoms. Trimethylaminuria is characterized primarily by a fishy odor that occurs when excess trimethylamine is released in the person's sweat, urine, reproductive fluids, and breath. Although some affected people may have a constant strong odor, most have a moderate odor that can vary in intensity.

Are you born with TMAU?

Trimethylaminuria symptoms can be present from birth, but they may not start until later in life, often around puberty. The only symptom is an unpleasant smell, typically of rotting fish – although it can be described as smelling like other things – that can affect the: breath. sweat.

How common is TMAU?

Trimethylaminuria is a rare metabolic disorder. More than 100 cases have been reported in the medical literature. Some clinicians believe that the disorder is under-diagnosed since many people with mild symptoms do not seek help.

What does TMAU smell like?

Trimethylaminuria is a disorder in which the body is unable to break down trimethylamine, a chemical compound that has a pungent odor. Trimethylamine has been described as smelling like rotting fish, rotting eggs, garbage, or urine. The intensity of the odor may vary over time.

How do you get tested for TMAU?


A urine test is used to diagnose trimethylaminuria. The person's urine is tested to look for higher levels of trimethylamine. Testing can be done by giving choline by mouth followed by urine collection a certain number of times over a 24 hour period.

Why do I smell like poop?

Sinus and respiratory infections can cause your breath to smell like feces. These can be caused by bronchitis, viral colds, strep throat, and more. When bacteria move from your nose into your throat, it can cause your breath to have an incredibly unpleasant odor.

Is TMAU hereditary?

TMAU is a genetic disease. A specific, hereditary gene hinders the body's ability to break down trimethtylamine (TMA), which is found mainly in choline-rich foods such as: Eggs. Wheat germ.

What does cancer smell like?

Cancer raises polyamine levels, and they do have a distinct odor. Using an electronic nose, researchers have been able to detect prostate cancer from urine smell print profiles. These studies, and others like them, are a promising area of cancer research. It's still in its infancy, though.

Can a mans sperm make you smell?

Semen, or seminal fluid, doesn't always smell the same. Semen contains numerous substances that influence its smell, and your individual diet, hygiene, and sex life all play a part. Certain foods can give it a sweet scent (and taste!). But eating or drinking acidic substances can make your semen smell foul.

Why is my body odor so strong suddenly?


Changes to body odor may be due to puberty, excessive sweating, or poor hygiene. Sudden changes are typically caused by the environment, medications, or foods that you eat. However, body odor, especially sudden and persistent changes to your normal odor, can sometimes be a sign of an underlying condition.

Why do I stink even after I shower?

There can be different reasons why a person has body odor. If you take a shower or bath and wash with lots of (antibacterial) soap such as Dial® and water, use deodorant, and wear clean clothes it is probably not due to poor hygiene.

How do you keep your VAG smelling good?

The following techniques may help you naturally eliminate unusual vaginal odors:
  1. Practice good hygiene. Clean the outside of your vagina regularly with a washcloth and mild soap.
  2. Use only exterior deodorizing products.
  3. Change your underwear.
  4. Consider a pH product.
  5. Try essential oils.
  6. Soak in vinegar.
  7. Prescription treatments.

Why does my bum smell like fish?

Is a fishy smell from hemorrhoids normal? It could be a sign of a number of issues but is more than likely smelly piles related. The smell is most likely anal discharge from the rectum produced by the mucus membrane as opposed to the leaking of faecal matter (poo) due to loss of sphincter control.

Is Trimethylaminuria dangerous?

Because many patients have associated body odours or halitosis, trimethylaminuria sufferers can meet serious difficulties in a social context, leading to other problems such as isolation and depression.

Why do I smell like poop after I poop?


Foul-smelling stools have an unusually strong, putrid smell. In many cases, foul-smelling stools occur due to the foods people eat and the bacteria present in their colon. However, foul-smelling stools can also indicate a serious health problem. Diarrhea, bloating, or flatulence may occur with foul-smelling stools.

What are phantom smells a sign of?

Brief episodes of phantom smells or phantosmia — smelling something that's not there — can be triggered by temporal lobe seizures, epilepsy, or head trauma. Phantosmia is also associated with Alzheimer's and occasionally with the onset of a migraine.

Does menopause make you smell?

Leakage of urine during menopause can cause an unwanted vaginal odor. In addition, a change of pH in the vagina, caused from fluctuating hormones, can also contribute to a vaginal odor. When this happens we feel betrayed that fresh feeling has gone.