How does sarcoidosis cause hypercalcemia?
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Regarding this, what causes sarcoidosis flare ups?
While no one knows what causes sarcoidosis, it is associated with increased immune system activity. This causes clusters of immune cells called granulomas to infiltrate your organs and lymph nodes. Sarcoidosis most commonly affects your lungs, but it can affect any organ in your body.
Likewise, does sarcoidosis cause high calcium? Many sarcoidosis patients tend to have an irregular calcium metabolism, and are generally affected with hypercalciuria — elevated levels of calcium in urine. Less commonly, some sarcoidosis patients develop hypercalcemia, which is high calcium levels in the blood.
Also to know is, how does vitamin D affect sarcoidosis?
It has been noted that excessive amounts of vitamin D are associated with a worse clinical outcome in sarcoidosis . In granulomas, there may be increased activity of 1-alpha hydroxylase. As part of the Th-1 immune response, calcitrol has a paracrine effect within the granuloma.
How does tuberculosis cause hypercalcemia?
Hypercalcemia in pulmonary tuberculosis is due to excessive extra-renal 1-alpha hydroxylase activity, and hence, limiting oral Vitamin D and calcium supplements is one of the major interventions in the treatment of hypercalcemia due to tuberculosis.