Does succinylcholine cause histamine release?

Asked By: Lorina Rheinheimer | Last Updated: 23rd January, 2020
Category: food and drink food allergies
4/5 (183 Views . 41 Votes)
As with other neuromuscular blocking agents, the potential for releasing histamine is present following succinylcholine administration. Signs and symptoms of histamine-mediated release such as flushing, hypotension, and bronchoconstriction are, however, uncommon in normal clinical usage.

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People also ask, what drugs cause histamine release?

Anaesthetic drugs that release histamine directly include atracurium, mivacurium, morphine and meperidine.

One may also ask, which muscle relaxants cause histamine release? Succinylcholine is a known trigger of malignant hyperthermia and can also cause hyperkalemia, postoperative muscle pain, and cardiac arrhythmias. Nondepolarizing drugs that cause histamine release (atracurium) or have sympathomimetic properties (pancuronium) can cause bronchospasms and tachycardia.

Also question is, does vecuronium cause histamine release?

Vecuronium rarely produces significant release of endogenous histamine.

What are the side effects of succinylcholine?

Common side effects of succinylcholine include:

  • Jaw rigidity.
  • Low blood pressure (hypotension)
  • Muscle fasciculation which may result in postoperative pain.
  • Muscle relaxation resulting in respiratory depression to the point of breathing cessation (apnea)
  • Respiratory depression.
  • Salivary gland enlargement.

32 Related Question Answers Found

What happens when you have too much histamine in your body?

Flushing is common. Peptic ulcers may develop because too much histamine is produced, stimulating secretion of excess stomach acid. Ulcers can cause stomach pain. Nausea, vomiting, and chronic diarrhea may also occur.

How do you remove histamine from your body?

Vitamins and minerals that may be good for people with histamine intolerance include:
  1. vitamin B-6, which helps DAO break down histamine.
  2. vitamin C to help lower histamine blood levels and help DAO break down histamine.
  3. copper, which helps raise DAO blood levels slightly and helps DAO break down histamine.

Is coffee high histamine?

Coffee is high in histamine which can set off what looks like an allergic reaction but it doesn't occur through the typical allergy mechanism. Instead, the histamine from the coffee causes an inflammatory reaction that can be quite severe in some people.

How can I reduce histamine in my body?

Controlling histamine levels with diet
  1. alcohol and other fermented beverages.
  2. fermented foods and dairy products, such as yogurt and sauerkraut.
  3. dried fruits.
  4. avocados.
  5. eggplant.
  6. spinach.
  7. processed or smoked meats.
  8. shellfish.

Are potatoes high in histamine?


Number 1: potato
It is well tolerated in many intolerances, contains important minerals, vitamins and protein. Formerly the potato was considered poor people food and fattening, but today it enjoys a reputation as a high-quality food. Even with histamine intolerance it is well tolerated.

Why do opioids release histamine?

Opioids can activate mast cell degranulation through direct stimulation and opioid receptor activation, thereby releasing of histamine. This mainly causes cutaneous reactions such as flushing, urticaria, and/or pruritus, which are commonly mislabeled as allergic reactions.

Why do opioids cause histamine release?

Opioids induce histamine release by directly activating mast cells and cause flushing or pruritus that is nearly always mislabeled as allergy symptoms [49] . It has been found that codeine and morphine are more prone to inducing mast cell degranulation than other opioids [50] .

Is Ibuprofen high in histamine?

According to a research report, NSAIDs such as aspirin, ibuprofen and naproxen can cause histamine levels to rise. Opoid drugs and analgesics are the most common drugs used in hospitals, releasing histamine that results in uncomfortable itching for many patients.

How does succinylcholine cause muscle relaxation?

Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site.

Is Mivacurium available in the US?


Mivacurium (Fig. 22.10) is the only short-acting nondepolarizing neuromuscular blocking agent available. While its availability in the United States has decreased since 2006, it is available throughout Europe.

What is the best muscle relaxer?

Which Muscle Relaxants Are Best for Neck and Back Pain?
  • 1) Methocarbamol. Methocarbamol (Robaxin) is a well-studied medication that treats back pain.
  • 2) Cyclobenzaprine.
  • 3) Carisoprodol.
  • 4) Metaxalone.
  • 5) Tizanidine.
  • 6) Baclofen.
  • 7) Oxazepam and diazepam.

What is curare poisoning?

Curare was used as a paralyzing poison by South American indigenous people. The prey was shot by arrows or blowgun darts dipped in curare, leading to asphyxiation owing to the inability of the victim's respiratory muscles to contract.

What drug makes you paralyzed?

GHB is a powerful synthetic drug that has euphoric and sedative effects. The only FDA-approved medical use of GHB (Xyrem) is restricted for the treatment of patients with a rare neurological disorder called Narcolepsy who experience a condition characterized by weak or paralyzed muscles.

How do Depolarising muscle relaxants work?

There are two types, depolarizing and nondepolarizing. Depolarizing muscle relaxants acts as ACh receptor agonists. They bind to the ACh receptors and generate an action potential. As the muscle relaxant continues to bind to the ACh receptor, the end plate cannot repolarize, resulting in a phase I block.

How long does it take for rocuronium to wear off?


The total duration (time until spontaneous recovery to 90% of control twitch height) is 50 minutes. The mean time of spontaneous recovery of twitch response from 25 to 75 % (recovery index) after a bolus dose of 0.6 mg rocuronium bromide per kg body weight is 14 minutes.

What is the active ingredient in muscle relaxers?

What are the differences between skeletal muscle relaxants?
Generic name Brand name FDA approval (spasm-related)
baclofen Gablofen, Lioresal General spasticity
carisoprodol Soma, Vanadom Muscle spasms
chlorzoxazone Lorzone Muscle spasms
cyclobenzaprine Amrix, Flexeril, Fexmid Muscle spasms

Which drug is a Nondepolarizing muscle relaxant?

Most commonly used muscle relaxants act in this manner. Examples of nondepolarizing muscle relaxants include d-tubocurarine (Curare), pancuronium, metocurine, vecuronium, atracurium, mivacurium, and gallamine.