What is calcitriol made of?

Asked By: Sinziana Hall | Last Updated: 19th January, 2020
Category: medical health bone and joint conditions
4.9/5 (116 Views . 13 Votes)
Calcitriol is, strictly, the 1-hydroxylation product of calcifediol (25-OH vitamin D3), derived from cholecalciferol (vitamin D3), rather than the product of hydroxylations of ergocalciferol (vitamin D2). 1α,25-Dihydroxyergocalciferol (ercalcitriol) should be used for the vitamin D2 product.

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Similarly one may ask, is calcitriol the same as vitamin D?

Calcitriol is vitamin D3. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body. Calcitriol is also used to treat calcium deficiency (hypocalcemia) and metabolic bone disease in people who are receiving dialysis.

Also Know, which organs are involved in making calcitriol? The liver and kidneys convert vitamin D (produced in the skin and taken up in the diet), into the active hormone, which is called calcitriol. Active vitamin D helps to increase the amount of calcium the gut can absorb from eaten food into the bloodstream and also prevents calcium loss from the kidneys.

Beside this, what does calcitriol do in the body?

Calcitriol is a vitamin D3 analog. Vitamin D helps your body absorb calcium from the stomach. Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving dialysis.

How does calcitriol increase calcium absorption?

Calcitriol increases blood calcium levels ( [Ca2+] ) by promoting absorption of dietary calcium from the gastrointestinal tract and increasing renal tubular reabsorption of calcium thus reducing the loss of calcium in the urine.

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When should you take calcitriol?

Calcitriol comes as a capsule and a solution (liquid) to take by mouth. It usually is taken once a day or once every other day in the morning with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Does calcitriol lower blood pressure?

Effect of Calcitriol Supplementation on Blood Pressure in Older Adults. In conclusion, 1,000 IU/day of calcitriol for 6 weeks efficiently reduced systolic and diastolic blood pressure levels in this population of older adults presenting with high blood pressure (Clinical Trial Approbation NCT02047799).

How long does calcitriol stay in your system?

Following multiple-dose administration, serum Calcitriol levels reached steady-state within 7 days. Calcitriol is approximately 99.9% bound in blood.

Can you take calcitriol and vitamin D together?

To avoid possible additive effects of taking two different forms of vitamin D, it's recommended that patients not take other forms of vitamin D or its derivatives while being treated with calcitriol. Patients are also advised to avoid an abrupt increase in dietary calcium intake, as it may trigger hypercalcemia.

Is calcitriol a vitamin?


Vitamin D (Calcitriol) Bioactive vitamin D or calcitriol is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, and in mineralization of bone.

Can you take calcitriol and calcium together?

Since calcitriol also increases calcium levels, taking these two types of medications together may cause hypercalcemia (abnormally highly levels of calcium). Calcitriol should be used cautiously in patients taking digoxin (Lanoxin).

What is calcitriol prescribed for?

Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving dialysis. Calcitriol is also used to treat calcium deficiency (hypocalcemia) and metabolic bone disease in people who are receiving dialysis.

Where is calcitriol produced?

Calcitriol is produced in the cells of the proximal tubule of the nephron in the kidneys by the action of 25-hydroxyvitamin D3 1-alpha-hydroxylase, a mitochondrial oxygenase and an enzyme which catalyzes the hydroxylation of 25-hydroxycholecalciferol (calcifediol) in the 1-alpha position.

Is calcitriol bad for kidneys?

What causes mineral and bone disorder in chronic kidney disease? stop activating calcitriol. The low levels of calcitriol in the body create an imbalance of calcium in the blood. do not remove the phosphorus in the blood properly, so phosphorus levels rise in the blood.

Can calcitriol cause high blood pressure?


There are several possible mechanisms underlying the effect of calcitriol on blood pressure. PTH has been found to be associated with an increase in blood pressure,9323334 and the parathyroid glands have receptors for calcitriol.

Can I stop taking calcitriol?

Do not stop taking Calcitriol-AFT or change the dose without first checking with your doctor. Stopping suddenly can lead in a rapid fall in blood calcium levels.

Can calcitriol cause kidney stones?

Calcitriol (1,25-Dihydroxyvitamin D) and Absorptive Hypercalciuria. The main component of kidney stones is calcium oxalate, and, to a lesser extent, calcium phosphate. Increased urinary calcium excretion or hypercalciuria is one of the main risk factors promoting calcium kidney stone formation.

Can you overdose on calcitriol?

Administration of Rocaltrol (calcitriol) to patients in excess of their daily requirements can cause hypercalcemia, hypercalciuria, and hyperphosphatemia. Since calcitriol is a derivative of vitamin D, the signs and symptoms of overdose are the same as for an overdose of vitamin D (see ADVERSE REACTIONS).

Can I take calcitriol with Synthroid?


No interactions were found between calcitriol and Synthroid. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Do I need a prescription for calcitriol?

Calcitriol, marketed under the brand Rocaltrol, is a medication used in the management of hypocalcemia (low calcium levels) in some patients. People who need a calcitriol prescription can connect with a local medical provider using Push Health who can prescribe Rocaltrol when it is appropriate to do so.

Does calcitriol increase vitamin D levels?

Calcitriol was associated with a significant increase in bone mineral density at the lumbar spine in patients with low vitamin D levels. However, their effects in the treatment of vitamin D deficiency compared to cholecalciferol are not clear.