Where is active vitamin D produced?
Likewise, where is vitamin D activated?
Vitamin D obtained from sun exposure, food, and supplements is biologically inert and must undergo two hydroxylations in the body for activation. The first occurs in the liver and converts vitamin D to 25-hydroxyvitamin D [25(OH)D], also known as calcidiol.
Subsequently, question is, how does vitamin D get produced? INTRODUCTION. Vitamin D3 is produced in the skin from 7-dehydrocholesterol by UV irradiation, which breaks the B ring to form pre-D3. Pre-D3 isomerizes to D3 or with continued UV irradiation to tachysterol and lumisterol. D3 is preferentially removed from the skin, bound to DBP.
Thereof, how vitamin D is made in the skin?
The skin is responsible for producing vitamin D. During exposure to sunlight, ultraviolet radiation penetrates into the epidermis and photolyzes provitamin D3 to previtamin D3. Therefore, the skin is the site for the synthesis of vitamin D and a target tissue for its active metabolite.
Where is Vitamin D metabolized in the body?
Metabolism to the Active Hormonal Form. Vitamin D, regardless of origin, is an inactive prohormone and must first be metabolized to its hormonal form before it can function. Once vitamin D enters the circulation from the skin or from the lymph, it is cleared by the liver or storage tissues within a few hours.