How does calcitonin decrease calcium?

Asked By: Maud Siemss | Last Updated: 5th March, 2020
Category: medical health thyroid disorders
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Calcitonin is involved in helping to regulate levels of calcium and phosphate in the blood, opposing the action of parathyroid hormone. Calcitonin reduces calcium levels in the blood by two main mechanisms: It inhibits the activity of osteoclasts, which are the cells responsible for breaking down bone.

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Subsequently, one may also ask, can calcitonin cause hypocalcemia?

When bone turnover is very high, calcitonin-mediated suppression of osteoclast activity can lead to hypocalcemia, and this phenomenon is utilized in the treatment of hypercalcemia with calcitonin. After calcitonin-induced hypocalcemia, compensatory activation of the PTH-vitamin D axis occurs to normalize serum calcium.

Similarly, what causes calcitonin? Calcitonin is a hormone that the C-cells in the thyroid gland produce and release. It opposes the action of the parathyroid hormone, helping to regulate the blood's calcium and phosphate levels. How does calcitonin work? Calcitonin works to control calcium and potassium levels.

Correspondingly, does calcitonin increase or decrease blood calcium levels?

Parathyroid hormone acts to increase blood calcium levels, while calcitonin acts to decrease blood calcium levels. This interaction between parathyroid hormone and calcitonin is also an important part of bone remodeling.

How is calcitonin stimulated?

Calcitonin secretion is stimulated by increases in the serum calcium concentration and calcitonin protects against the development of hypercalcemia. Calcitonin is also stimulated by gastrointestinal hormones such as gastrin.

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What happens when you have too much calcitonin?

If too much calcitonin is found in the blood, it may be a sign of a type of thyroid cancer called medullary thyroid cancer (MTC). High levels may also be a sign of other thyroid diseases that can put you at a higher risk for getting MTC.

Does calcitonin build bone?

Calcitonin is a hormone naturally produced in the thyroid. When given to patients with osteoporosis, calcitonin produces modest increases in bone mass because it slows the rate at which osteoclasts absorb bone. Only women who are at least five years past menopause can take calcitonin.

How does calcitonin affect the kidneys?

Physiologic Effects of Calcitonin
Bone: Calcitonin suppresses resorption of bone by inhibiting the activity of osteoclasts, a cell type that "digests" bone matrix, releasing calcium and phosphorus into blood. Kidney: Calcium and phosphorus are prevented from being lost in urine by reabsorption in the kidney tubules.

What does calcitonin do for the body?

Calcitonin reduces calcium levels in the blood by two main mechanisms: It inhibits the activity of osteoclasts, which are the cells responsible for breaking down bone. When bone is broken down, the calcium contained in the bone is released into the bloodstream.

Does TSH affect calcitonin?

TSH is released from the pituitary gland into the bloodstream and travels to the thyroid gland. Here, TSH causes cells within the thyroid gland to make more T3 and T4. These cells cause calcium to be released as they 'clean' bone. Calcitonin also accelerates the amount of calcium and phosphorus taken up by bone.

How long can you take calcitonin?

Calcitonin is used as a short-term treatment (for 2–4 weeks) to help prevent bone loss if you're immobilised following an osteoporotic fracture. It may be given by injection: under the skin (subcutaneous injection) into a muscle (intramuscular injection).

What are the side effects of calcitonin?

Nausea, abdominal pain, diarrhea, vomiting, or flushing may occur. Using this medication at bedtime may help to decrease these side effects. Swelling/redness at injection site, a salty taste in mouth, increased urination, or loss of appetite may also occur.

What is considered a high calcitonin level?

Patients with calcitonin levels >100 pg/mL have a high risk for medullary thyroid carcinoma (~90%–100%), whereas patients with values from 10 to 100 pg/mL (normal values: <8.5 pg/mL for men, < 5.0 pg/mL for women; immunochemiluminometric assay) have a <25% risk for medullary thyroid carcinoma.

What are normal calcitonin levels?

Normal Results
A normal value is less than 10 pg/mL. Women and men can have different normal values, with men having higher values. Sometimes, calcitonin in the blood is checked several times after you are given a shot (injection) of a special medicine that stimulates calcitonin production.

What kind of cancer does calcitonin cause?

Calcitonin-producing tumor
An experiment of nature is medullary thyroid cancer (MTC), an unusual but not rare tumor of the parafollicular (C) cells of the thyroid.

What effect does calcitonin have on blood calcium levels?

The hormone calcitonin, which is produced by the parafollicular or C cells of the thyroid, has the opposite effect on blood calcium levels as does PTH. Calcitonin decreases blood calcium levels by inhibiting osteoclasts, stimulating osteoblasts, and stimulating calcium excretion by the kidneys.

How are calcium levels maintained in the blood and bone?

Calcium release from bone is regulated by parathyroid hormone. Calcitriol regulates the levels of calcium and phosphorus in the blood and helps maintain a healthy skeletal system. Bone resorption by osteoclasts releases calcium into the bloodstream, which helps regulate calcium homeostasis.

What helps calcium absorption?

In addition to vitamin D, vitamin C, vitamin E, vitamin K, magnesium, and boron assist in absorbing calcium and also increasing bone mass. Exercise also helps the body absorb calcium. Because the body has a hard time absorbing a large amount of calcium at once, spreading out the intake of calcium is recommended.

What hormone controls the breakdown of bone?

Parathyroid hormone (PTH) is an important contributor to the bone remodeling process. High levels of PTH can activate osteoclasts and cause excessive bone breakdown. Calcium in your blood triggers the release of PTH. Low calcium levels in the blood, or hypocalcemia, can cause high levels of PTH.

What inhibits the absorption of calcium?

Not all calcium consumed is actually absorbed in the gut. Other components in food: phytic acid and oxalic acid, found naturally in some plants, bind to calcium and can inhibit its absorption. Foods with high levels of oxalic acid include spinach, collard greens, sweet potatoes, rhubarb, and beans.

Is calcitonin a steroid?

Calcitonin. Chr. Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid gland in humans, and in many other animals in the ultimopharyngeal body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).