Why is Kayexalate given for hyperkalemia?

Asked By: Emin Eretrg | Last Updated: 22nd April, 2020
Category: medical health heart and cardiovascular diseases
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Kayexalate (Sodium polystyerene sulfonate) is a cation-exchange resin that was approved in 1958 as a treatment for hyperkalemia by helping to exchange sodium for potassium in the colon and thus excreting potassium from the body. This drug has been a standard part of treatment of hyperkalemia for decades.

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Also know, what does Kayexalate do to potassium?

Kayexalate binds itself to potassium in your digestive tract. This helps prevent your body from absorbing too much potassium. Kayexalate is used to treat high levels of potassium in the blood, also called hyperkalemia.

One may also ask, why is sodium bicarbonate used to treat hyperkalemia? Intravenous calcium to temporarily protect the heart and muscles from the effects of hyperkalemia. Sodium bicarbonate administration to counteract acidosis and to promote movement of potassium from the extracellular space back into the cells.

Similarly, why is Kayexalate used in renal patients?

Sodium polystyrene sulfonate (SPS) (Kayexalate®) is a cation exchange resin that trades sodium ions for potassium ions, mostly in the large intestine, to enhance the fecal elimination of excess potassium. As patients progress to higher stages of CKD, the only definitive therapy for hyperkalemia is dialysis.

What medications are used to treat hyperkalemia?

Other treatment options for hyperkalemia include IV calcium, insulin, sodium bicarbonate, albuterol, and diuretics. A new drug (patiromer) was recently approved for the treatment of hyperkalemia, and additional agents are also in development.

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How quickly does Kayexalate work?

Many of us were taught that if you give a patient a dose of kayexalate, you should expect there serum potassium to drop by 0.5 – 1.0 mEq in 4-6 hours.

Can you mix Kayexalate with juice?

KAYEXALATE powder is usually given by mouth mixed in a small amount of water. It can also be mixed with food or sweetened liquid Do NOT mix KEYEXALATE with orange juice or fruit juice which contains potassium. The doctor may change the dose or stop the KAYEXALATE depending on what the results of these blood tests are.

How can I lower my potassium level?

Home remedies for reducing potassium
  1. Reduce your potassium intake. One of the easiest ways to lower your potassium levels naturally is to reduce the amount of potassium in your diet.
  2. Check your salt substitutes. Some salt substitutes are also high in potassium.
  3. Drink more water.
  4. Avoid certain herbs.

What are the side effects of Kayexalate?

Common side effects of Kayexalate include:
  • loss of appetite,
  • upset stomach,
  • nausea,
  • vomiting,
  • constipation, or.
  • diarrhea.

What level of potassium is dangerous?


Potassium is a chemical that is critical to the function of nerve and muscle cells, including those in your heart. Your blood potassium level is normally 3.6 to 5.2 millimoles per liter (mmol/L). Having a blood potassium level higher than 6.0 mmol/L can be dangerous and usually requires immediate treatment.

How much does Veltassa lower potassium?

VELTASSA is a sodium-free prescription medicine that helps reduce potassium levels in the blood. In a clinical study, up to 95% of people taking VELTASSA reduced their potassium levels and kept them normal (3.8 to <5.1 mEq/L) over time.

What is the emergency treatment for hyperkalemia?

Drugs used in the treatment of hyperkalemia include the following: Calcium (either gluconate or chloride): Reduces the risk of ventricular fibrillation caused by hyperkalemia. Insulin administered with glucose: Facilitates the uptake of glucose into the cell, which results in an intracellular shift of potassium.

Does Kayexalate give you diarrhea?

KAYEXALATE may cause some degree of gastric irritation. Anorexia, nausea, vomiting, and constipation may occur especially if high doses are given. Also, hypokalemia, hypocalcemia, and significant sodium retention, and their related clinical manifestations, may occur (see WARNINGS). Occasionally diarrhea develops.

What should I eat if my potassium is too high?

This means that potassium can build up in your blood to harmful levels. Eat a diet high in potassium. Eating too much food that is high in potassium can also cause hyperkalemia, especially in people with advanced kidney disease. Foods such as melons, orange juice, and bananas are high in potassium.

Is Kayexalate nephrotoxic?


Sodium polystyrene sulfonate belongs to the class of medications called cation-exchange resins. It is used to treat high levels of potassium in the blood (hyperkalemia). It lowers the level of potassium in the blood by binding to potassium in the intestine.

What causes high potassium?

Kidney disease is the most common cause of hyperkalemia. Diseases that lower the production of this hormone, such as Addison's disease, can lead to hyperkalemia. Too much potassium in the diet can also contribute to higher levels in your blood, if your kidneys don't work well or you take certain medicines.

What drug class is Kayexalate?

KAYEXALATE is a non-absorbed, cation exchange polymer that contains a sodium counterion. KAYEXALATE increases fecal potassium excretion through binding of potassium in the lumen of the gastrointestinal tract.

How long does it take for sodium polystyrene to work?

However, actual removal of potassium in patients is closer to 1 mEq per gram of medication. Sodium polystyrene sulfonate starts working over a period of several hours and therefore should not be used to treat life-threatening episodes of acute hyperkalemia.

Is Kayexalate potassium sparing?

When you lose fluid through the kidneys, you will lose potassium as well. Sodium polystyrene sulfonate (e.g.Kayexalate) - This medication works to lower blood potassium levels by binding with the potassium in your stomach or gut.

Can Kayexalate be given daily?


2.2 Recommended Dosage
The average total daily adult dose of KAYEXALATE is 15 g to 60 g, administered as a 15-g dose (four level teaspoons), one to four times daily. The average adult dose is 30 g to 50 g every six hours.

How do you administer Kayexalate suspension?

If you are taking this medication by mouth, take it usually 1 to 4 times a day as directed by your doctor. To prepare the liquid suspension, carefully measure the prescribed dose of the powder and mix it with the prescribed amount of water or flavored syrup as directed. Stir well and drink the entire dose.

How do you get prescribed Kayexalate?

2.3 Preparation and Administration
One level teaspoon contains approximately 3.5 g of Kayexalate and 15 mEq of sodium. Suspend each dose in a small quantity of water or syrup, approximately 3 to 4 mL of liquid per gram of resin. Administer with patient in an upright position [see Warnings and Precautions (5.4)].