Why is creatinine a good indicator of renal function?
Also, what is the most reliable indicator of renal function?
Glomerular filtration rate is the best overall indicator of kidney function. It is superior to the serum creatinine level, which varies with age, sex, and race and often does not reflect kidney function accurately.
Subsequently, question is, how is creatinine used in the investigation of renal disease? Serum creatinine is commonly used to screen for renal disease or to investigate urinary sediment abnormalities, hypertension or non-specific symptoms such as tiredness. Creatinine generation from the muscles is proportional to the total muscle mass and muscle catabolism.
Also Know, why is creatinine high in renal failure?
Elevated creatinine level signifies impaired kidney function or kidney disease. As the kidneys become impaired for any reason, the creatinine level in the blood will rise due to poor clearance of creatinine by the kidneys. Abnormally high levels of creatinine thus warn of possible malfunction or failure of the kidneys.
What is creatinine a marker of?
Diagnostic serum creatinine studies are used to determine renal function. Measuring serum creatinine is a simple test, and it is the most commonly used indicator of renal function. A rise in blood creatinine concentration is a late marker, observed only with marked damage to functioning nephrons.