Why is creatinine a good indicator of renal function?

Asked By: Tingting Mitterfellner | Last Updated: 4th May, 2020
Category: medical health diabetes
4/5 (21 Views . 20 Votes)
Creatinine is found in serum, plasma, and urine and is excreted by glomerular filtration at a constant rate and in the same concentration as in plasma. Creatinine is a more reliable indicator of renal function than BUN because it is less influenced by other factors such as diet and hydration.

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Also, what is the most reliable indicator of renal function?

Glomerular filtration rate is the best overall indicator of kidney function. It is superior to the serum creatinine level, which varies with age, sex, and race and often does not reflect kidney function accurately.

Subsequently, question is, how is creatinine used in the investigation of renal disease? Serum creatinine is commonly used to screen for renal disease or to investigate urinary sediment abnormalities, hypertension or non-specific symptoms such as tiredness. Creatinine generation from the muscles is proportional to the total muscle mass and muscle catabolism.

Also Know, why is creatinine high in renal failure?

Elevated creatinine level signifies impaired kidney function or kidney disease. As the kidneys become impaired for any reason, the creatinine level in the blood will rise due to poor clearance of creatinine by the kidneys. Abnormally high levels of creatinine thus warn of possible malfunction or failure of the kidneys.

What is creatinine a marker of?

Diagnostic serum creatinine studies are used to determine renal function. Measuring serum creatinine is a simple test, and it is the most commonly used indicator of renal function. A rise in blood creatinine concentration is a late marker, observed only with marked damage to functioning nephrons.

37 Related Question Answers Found

Will drinking water increase my GFR?

Water ingestion can acutely affect GFR, although not necessarily in the direction one might expect. Using 12 young, healthy individuals as their own controls, Anastasio et al. found increased water intake actually decreases GFR.

What are the symptoms of stage 1 kidney disease?

The most common signs and symptoms of chronic kidney disease include:
  • anemia.
  • blood in urine.
  • dark urine.
  • decreased mental alertness.
  • decreased urine output.
  • edema – swollen feet, hands, and ankles (face if edema is severe)
  • fatigue (tiredness)
  • hypertension (high blood pressure)

What can cause high creatinine levels?

Some of the causes of high creatinine levels are:
  • Chronic kidney disease. Share on Pinterest Intense exercise can result in increased creatinine levels.
  • Kidney obstruction.
  • Dehydration.
  • Increased consumption of protein.
  • Intense exercise.
  • Certain medications.

What is considered a bad creatinine level?

Healthy kidneys remove creatinine from your blood. This means that a high serum (blood) level may be due to kidney damage. If two or more levels are high, you may have kidney disease. The normal serum creatinine range is 0.6–1.1 mg/dL in women and 0.7–1.3 mg/dL in men.

What color is urine when your kidneys are failing?


Brown, red, or purple urine
Kidneys make urine, so when the kidneys are failing, the urine may change.

How can I check my kidneys at home?

One of the best ways to test for CKD and assess kidney damage is a simple urine test which detects the presence of albumin. The smartphone app from Healthy.io enables lay users to conduct a urinalysis test at home and securely share results with their clinicians.

Is creatinine level 1.7 Dangerous?

When kidneys are not working well, creatinine builds up in the blood. One formula for estimating kidney function equates a creatinine level of 1.7 mg/dL for most men and 1.4 mg/dL for most women to 50 percent of normal kidney function.

What is poor renal function?

Chronic kidney disease, also called chronic kidney failure, describes the gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood, which are then excreted in your urine.

Can drinking water lower your creatinine levels?

Drinking more water could lower the serum creatinine level, but does not change kidney function. Forcing excessive water intake is not a good idea.

Is high creatinine levels reversible?


This can result in a self-limited and reversible increase in the serum creatinine level of as much as 0.4 to 0.5 mg/dL (depending on baseline serum creatinine level). As such, an increase in creatinine level suggests a true decrease in GFR only if accompanied by a corresponding increase in BUN levels.

What are the symptoms when creatinine is high?

Urinary tract blockage
Some signs to look out for in addition to a high creatinine level include: pain in your back or side. frequent or painful urination. blood in your urine.

What food should be avoided if creatinine is high?

Cooked red meat in particular can affect creatinine. The heat from cooking causes creatine found in meat to produce creatinine. People with diets very high in red meat or other protein sources, including dairy products, may have higher creatinine levels than people who eat less of those foods.

What drugs can increase creatinine levels?

High Creatinine Levels on Your Blood Test? Taking These 4 Drugs Can Cause a False Alarm
  • 1) Sulfamethoxazole / trimethoprim (Bactrim / Septra)
  • 2) Acid blockers — cimetidine (Tagamet) & ranitidine (Zantac)
  • 3) Cephalosporin antibiotics.
  • 4) Fenofibrate (Tricor)

At what creatinine level should dialysis start?

When kidney function is normal, creatinine is filtered from the blood through the kidneys. When creatinine levels are high, it can be an indicator of kidney disease. For adults, dialysis is recommended when estimated glomerular filtration rate (GFR) levels reach approximately 10.0 ml/min.

How can I improve my kidney function to avoid dialysis?


How to delay the onset of dialysis — at a glance
  1. Eat right and lose excess weight.
  2. Exercise regularly.
  3. Don't smoke.
  4. Avoid excess salt in your diet.
  5. Control high blood pressure.
  6. Control diabetes.
  7. Stay on the job and keep your health insurance.
  8. Talk with your health care team.

What is the creatinine level for stage 3 kidney disease?

Optimal cutoff values for serum creatinine in the diagnosis of stage 3 CKD in older adults were ≥1.3 mg/dl for men and ≥1.0 mg/dl for women, regardless of the presence or absence of hypertension, diabetes, or congestive heart failure.

What if bun is normal but creatinine is high?

Like BUN, high levels of creatinine could mean there is a lot of waste product that hasn't been removed by the kidneys. The ideal ratio of BUN to creatinine falls between 10-to-1 and 20-to-1. A ratio below the normal range could mean liver disease or malnutrition.