What is the selectivity of a drug?

Asked By: Danelle Schmith | Last Updated: 13th January, 2020
Category: medical health pharmaceutical drugs
4.4/5 (35 Views . 26 Votes)
The drugs then interact with cells or tissues where they produce their intended effects (target sites). This interaction is called selectivity. Selectivity is the degree to which a drug acts on a given site relative to other sites. Relatively nonselective drugs affect many different tissues or organs.

Click to see full answer

Thereof, why is drug selectivity important?

Drug Selectivity. Drug selectivity is an important aspect for evaluating the ADRs of drugs, and there is evidence that compound target promiscuity is largely correlated with its lipophilicity and ionization states.

Similarly, what is the difference between selectivity and specificity in pharmacology? It is important to understand that the term specificity is used to tell something about the method's ability responding to one single analyte only, while selectivity is used when the method is able to respond to several different analytes in the sample.

Besides, what is specificity of a drug?

If a drug has one effect, and only one effect on all biological systems it possesses the property of specificity.

What is potency of a drug?

In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.

36 Related Question Answers Found

What is the efficacy of a drug?

Efficacy is the ability to get a job done to a satisfactory degree. The word efficacy is used in pharmacology and medicine to refer both to the maximum response achievable from a pharmaceutical drug in research settings, and to the capacity for sufficient therapeutic effect or beneficial change in clinical settings.

How do drugs act on the body?

The action of drugs on the human body is called pharmacodynamics, and what the body does with the drug is called pharmacokinetics. The drugs that enter the human tend to stimulate certain receptors, ion channels, act on enzymes or transporter proteins. As a result, they cause the human body to react in a specific way.

What is meant by target specificity and selectivity Why is it important?

Target specificity and selectivity is a crucial factor in modern medicinal chemistry research. The more selective a drug is for its target, the less chance there is that it will. interact with different targets and have undesirable side effects.

How do drugs reach their site of action?

Targets in The Body: Cell Receptors
When these substances bind with the receptor on a cell, they stimulate that receptor to perform its function, which is to produce or to inhibit a specific action in the cell. Drugs can also target and bind with these receptors.

How is drug affinity measured?

Affinity is a measure of the tightness with which a drug binds to the receptor. Intrinsic activity is a measure of the ability of a drug that is bound to the receptor to generate an activating stimulus and produce a change in cellular activity. Both agonists and antagonists can bind to a receptor.

What is a selectivity coefficient?

A selectivity coefficient is the equilibrium constant for the reaction of displacement by one ligand of another ligand in a complex with the substrate. Binding selectivity is of major importance in biochemistry and in chemical separation processes.

What is Drug Action in pharmacology?

In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor.

What is a good therapeutic index?

A ratio that compares the blood concentration at which a drug becomes toxic and the concentration at which the drug is effective. The larger the therapeutic index (TI), the safer the drug is.

What is difference between sensitivity and specificity?

In medical diagnosis, test sensitivity is the ability of a test to correctly identify those with the disease (true positive rate), whereas test specificity is the ability of the test to correctly identify those without the disease (true negative rate).

What are drugs side effects?

In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.

Which drug acts as an enzyme inducer?

Examples of enzyme inducers include aminoglutethimide, barbiturates, carbamazepine, glutethimide, griseofulvin, phenytoin, primidone, rifabutin, rifampin, and troglitazone. Some drugs, such as ritonavir, may act as either an enzyme inhibitor or an enzyme inducer, depending on the situation.

How is pharmacodynamics best defined?

Pharmacodynamics is defined as the response of the body to the drug. It refers to the relationship between drug concentration at the site of action and any resulting effects namely, the intensity and time course of the effect and adverse effects. Pharmacognosy is the study of drugs derived from natural sources.

Is mechanism of action the same as pharmacodynamics?

Pharmacodynamics is the study of the biochemical and physiologic effects of drugs and their mechanisms of action on the body or on microorganisms and other parasites within or on the body. Not all drugs exert their pharmacologic actions via receptor-mediated mechanisms.

What effect does an agonist drug have on its respective receptor?

Agonists and antagonists
Agonists activate receptors to produce the desired response. Conventional agonists increase the proportion of activated receptors. Inverse agonists stabilize the receptor in its inactive conformation and act similarly to competitive antagonists.

What is the method validation?

Method validation is the process used to confirm that the analytical procedure employed for a specific test is suitable for its intended use. Results from method validation can be used to judge the quality, reliability and consistency of analytical results; it is an integral part of any good analytical practice.

Why is method validation important?

The purpose of validation. Method validation is a key activity in chemical analysis, indispensable for obtaining reliable results. This information is relevant both to the laboratory (to be confident in your results or to make adequate changes in method if the performance is not as expected) as well as for the customer