What is the difference between inactivated vaccine and attenuated vaccine?

Asked By: Lemuel Peierl | Last Updated: 9th February, 2020
Category: medical health vaccines
4.7/5 (62 Views . 26 Votes)
Live virus vaccines use the weakened (attenuated) form of the virus. Killed (inactivated) vaccines are made from a protein or other small pieces taken from a virus or bacteria. The whooping cough (pertussis) vaccine is an example. Toxoid vaccines contain a toxin or chemical made by the bacteria or virus.

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Simply so, what are the 3 Live vaccines?

Live-attenuated vaccines

  • Measles, mumps, rubella (MMR combined vaccine)
  • Rotavirus.
  • Smallpox.
  • Chickenpox.
  • Yellow fever.

Also Know, is hepatitis B vaccine live or inactivated? The vaccines should be given at a separate site, preferably in a different arm or leg. The vaccine does not contain any live viruses, and cannot cause hepatitis B disease. Since the disease is so serious, the World Health Organization has said that all babies in the world should be protected by hepatitis B vaccination.

Likewise, what is meant by inactivated vaccine?

An inactivated vaccine (or killed vaccine) is a vaccine consisting of virus particles, bacteria, or other pathogens that have been grown in culture and then lose disease producing capacity. Inactivated vaccines are further classified depending on the method used to inactivate the virus.

What is a live attenuated vaccine mean?

An attenuated vaccine is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable (or "live"). Attenuation takes an infectious agent and alters it so that it becomes harmless or less virulent. These vaccines contrast to those produced by "killing" the virus (inactivated vaccine).

39 Related Question Answers Found

What vaccines are live vaccines?

Live virus vaccines use the weakened (attenuated) form of the virus. The measles, mumps, and rubella (MMR) vaccine and the varicella (chickenpox) vaccine are examples. Killed (inactivated) vaccines are made from a protein or other small pieces taken from a virus or bacteria.

Which vaccines are live CDC?

Currently available live attenuated viral vaccines are measles, mumps, rubella, vaccinia, varicella, zoster (which contains the same virus as varicella vaccine but in much higher amount), yellow fever, rotavirus, and influenza (intranasal).

Can I get a flu shot and shingles vaccine at the same time?

The influenza vaccine did not affect the immune response. The influenza vaccine can be administered on the same day as Shingrix as separate injections. Shingrix is more effective than Zostavax; however, there are no head-to-head trials comparing both. The overall vaccine efficacy against herpes zoster was 97.2% (P<.

Is tetanus a live vaccine?

They are known as “inactivated” vaccines because they do not contain live bacteria and cannot replicate themselves, which is why multiple doses are needed to produce immunity. What's the difference between all the vaccines containing diphtheria and tetanus toxoids and pertussis vaccine?

Can you get sick from vaccines?


Q: Can a child get a disease even after being vaccinated? A: It isn't very common, but it can happen. Depending on the vaccine, about 1% to 5% of children who are vaccinated fail to develop immunity. If these children are exposed to that disease, they could get sick.

How do live attenuated vaccines work?

Live, attenuated vaccines fight viruses and bacteria. These vaccines contain a version of the living virus or bacteria that has been weakened so that it does not cause serious disease in people with healthy immune systems. Inactivated vaccines produce immune responses in different ways than live, attenuated vaccines.

How do they weaken a virus for vaccines?

There are four ways that viruses and bacteria are weakened to make vaccines: Change the virus blueprint (or genes) so that the virus replicates poorly. This is how the measles, mumps, rubella, and varicella vaccines are made. Destroy the virus blueprint (or genes) so that the virus can't replicate at all.

How do you develop a vaccine?

Vaccine production has several stages. First, the antigen itself is generated. Viruses are grown either on primary cells such as chicken eggs (e.g., for influenza) or on continuous cell lines such as cultured human cells (e.g., for hepatitis A). Bacteria are grown in bioreactors (e.g., Haemophilus influenzae type b).

How does an inactivated vaccine work?

Inactivated Vaccines: For these vaccines, the specific virus or bacteria is killed with heat or chemicals, and its dead cells are introduced into the body. Even though the pathogen is dead, the immune system can still learn from its antigens how to fight live versions of it in the future.

Can an inactivated vaccine cause disease?


Inactivated vaccines are made from microorganisms (viruses, bacteria, other) that have been killed through physical or chemical processes. These killed organisms cannot cause disease. may not be long lived.

How is an inactivated vaccine made?

Inactivated vaccines are made using 'wild' viruses or bacteria that have been grown in a culture medium and inactivated before being included in a vaccine, or made using a toxin, protein or polysaccharide (sugar) fragment derived from viruses or bacteria (subunit vaccines). Nothing in an inactivated vaccine is alive.

What does toxoid vaccine mean?

Toxoid vaccines Toxoid vaccineA vaccine made from a toxin (poison) that has been made harmless but that elicits an immune response against the toxin. are based on the toxin produced by certain bacteria (e.g. tetanus or diphtheria).

What confers passive immunity?

Passive immunity is the administration of antibodies to an unimmunized person from an immune subject to provide temporary protection against a microbial agent or toxin. This type of immunity can be conferred on persons who are exposed to measles, mumps, whooping cough, poliomyelitis,…

Is Typhoid a live vaccine?

There are two vaccines to prevent typhoid fever. One is an inactivated (killed) vaccine and the other is a live, attenuated (weakened) vaccine.

What is a recombinant vaccine?


A recombinant vaccine is a vaccine produced through recombinant DNA technology. This involves inserting the DNA encoding an antigen (such as a bacterial surface protein) that stimulates an immune response into bacterial or mammalian cells, expressing the antigen in these cells and then purifying it from them.

What is genetic vaccine?

Gene vaccines are a new approach to immunization and immunotherapy in which, rather than a live or inactivated organism (or a subunit thereof), one or more genes that encode proteins of the pathogen are delivered.

Do vaccines shed?

Viral shedding is part of the mechanism of virus transmission. Shedding is impossible with killed vaccines or those made using only isolated proteins (most vaccines fall into one of these two classes), but a small number of vaccines contain live attenuated virus which can theoretically infect others.