What is idiosyncratic toxicity?

Idiosyncratic toxicity: a convergence of risk factors. Generally, toxicity is dose-dependent and is driven either by the therapeutic target or by an untoward target. However, idiosyncratic toxicities are usually not observed until a drug has been on the market and has gained broad exposure.

Also, what is an example of an idiosyncratic reaction?

Idiosyncratic reactions are unpredictable and not explained by the pharmacologic properties of the drug. An example is the individual with infectious mononucleosis who develops a rash when given ampicillin.

Also Know, which response can be considered idiosyncratic? Uetrecht and Naisbitt (209) defined an idiosyncratic drug reaction as, “an adverse reaction that does not occur in most patients treated with a drug and does not involve the therapeutic effect of the drug … they are unpredictable and often life threatening.”

Similarly one may ask, what is an idiosyncratic effect?

Noun. idiosyncratic reaction (plural idiosyncratic reactions) (pharmacy, medicine) A reaction to a medication that is unusual and unpredictable, specific to a particular person. Unlike allergy, it can occur on first exposure to the medication; unlike a side effect, it affects only very few individuals.

What is idiosyncratic hepatotoxicity?

Idiosyncratic hepatotoxicity is most often not related to a drug's pharmacological action. In an unstressed individual, the liver may not appear as a target for toxicity for a drug because the doses needed to cause hepatotoxicity are very large.

27 Related Question Answers Found

What is idiosyncratic thinking?

It involves a judgment of positive thought disorder in the response as a whole and is based on the scorer's understanding of the definition of bizarre-idiosyncratic thinking as well as on the coherence and appropriateness of the response.

What is a toxic reaction?

A toxic reaction occurs when insect or spider venom acts like a poison in the body. This type of reaction can occur from one bite or sting from a highly toxic insect or spider, or from multiple bites or stings from insects or spiders not normally considered poisonous.

What is an idiosyncratic person?

adjective. The definition of idiosyncratic is quirky or peculiar, or the temperament which is unique to an individual. An example of an idiosyncratic person is someone who does a lot of out of the ordinary things. An example of an idiosyncratic trait is the way a person always deals with disappointment.

What is the nature of a drug idiosyncrasy?

"Drug idiosyncrasy" refers to untoward reactions to drugs that occur in a small fraction of patients and have no obvious relationship to dose or duration of therapy. The liver is a frequent target for toxicity.

What is an example of an idiosyncrasy?

Use idiosyncrasy in a sentence. noun. The definition of an idiosyncrasy is an unusual behavior, mannerism or reaction of a person or group of people. An example of idiosyncrasy is someone being allergic to air.

What is a Type B drug?

Adverse drug reactions (ADRs) are increasingly common and are a significant cause of morbidity and mortality. Type B reactions are idiosyncratic, bizarre or novel responses that cannot be predicted from the known pharmacology of a drug and are associated with low morbidity and high mortality.

What type of drug is atropine?

anticholinergic

What is a genetically caused abnormal response to normal doses of a drug?

Idiosyncratic ADRs are unexpected ADRs that are not dose-related or allergic. They occur in a small percentage of patients given a drug. Idiosyncrasy is an imprecise term that has been defined as a genetically determined abnormal response to a drug, but not all idiosyncratic reactions have a pharmacogenetic cause.

What is drug interaction mean?

A drug interaction is a reaction between two (or more) drugs or between a drug and a food, beverage, or supplement. Taking a drug while having certain medical conditions can also cause a drug interaction. A drug interaction can affect how a drug works or cause unwanted side effects.

What is an allergic response?

An allergic response is a hypersensitive immune reaction to a substance that normally is harmless or would not cause an immune response in everyone. An allergic response may cause harmful symptoms such as itching or inflammation or tissue injury.

What does cumulative effect mean?

Noun. cumulative effect (plural cumulative effects) The state in which a series of repeated actions have an effect greater than the sum of their individual effects; noted especially in the repeated administration of drugs or repeated consumption of trace elements or chemicals that show no immediate effect.

When drugs have the opposite effect?

A paradoxical reaction or paradoxical effect is an effect of a chemical substance, mostly a medical drug, opposite to the effect which would normally be expected. An example of a paradoxical reaction is pain caused by a pain relief medication.

What causes allergy?

Allergies occur when your immune system reacts to a foreign substance — such as pollen, bee venom or pet dander — or a food that doesn't cause a reaction in most people. Your immune system produces substances known as antibodies.

What is allergy in pharmacology?

Specialty. Immunology, pharmacology. A drug allergy is an allergy to a drug, most commonly a medication, and is a form of adverse drug reaction. Medical attention should be sought immediately if an allergic reaction is suspected. An allergic reaction will not occur on the first exposure to a substance.

What is idiosyncrasy in pharmacology?

In pharmacology, idiosyncrasy refers to an idiosyncratic reaction, which is an adverse effect to an agent, such as a drug, which does not occur in most patients who've used the same agent. In lay terms, when we say someone has a certain idiosyncrasy, we refer to a habit or mannerism that's peculiar to that person.

What does it mean when you develop a tolerance for a medication?

6: Definition of tolerance. When drugs such as heroin are used repeatedly over time, tolerance may develop. Tolerance occurs when the person no longer responds to the drug in the way that person initially responded. Thus, the effect of a given dose of morphine or heroin is diminished.

What are some examples of adverse drug events?

Examples of such adverse drug reactions include rashes, jaundice, anemia, a decrease in the white blood cell count, kidney damage, and nerve injury that may impair vision or hearing. These reactions tend to be more serious but typically occur in a very small number of people.