What is chloroquine resistance?
Similarly one may ask, what is chloroquine resistant malaria?
Chloroquine-resistant malaria. falciparum, the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in PfCRT, a protein that likely functions as a transporter in the parasite's digestive vacuole membrane.
Also, what is the mechanism of action of chloroquine? The major action of chloroquine is to inhibit the formation of hemozoin (Hz) from the heme released by the digestion of hemoglobin (Hb). The free heme then lyses membranes and leads to parasite death. Chloroquine resistance is due to a decreased accumulation of chloroquine in the food vacuole.
Beside above, what is drug resistance in malaria?
Antimalarial drug resistance In the 1970s and 1980s, Plasmodium falciparum – the parasite species responsible for the most common and most deadly form of malaria – developed widespread resistance to previous antimalarial medicines, such as chloroquine and sulfadoxine-pyrimethamine (SP).
How do parasites become resistant to drugs?
After an animal is treated with an antiparasitic drug, the susceptible parasites die and the resistant parasites survive to pass on resistance genes to their offspring.