What does RPR non reactive mean?

Asked By: Cheikhou Consolina | Last Updated: 28th February, 2020
Category: medical health infectious diseases
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Rapid plasma reagin is commonly abbreviated RPR. A negative ("nonreactive") RPR test result is compatible with a person not having syphilis. However, a person may have a negative RPR test and still have syphilis since, in the early stages of the disease, the RPR often gives negative results.

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Moreover, what does a non reactive syphilis test mean?

A negative or nonreactive result means you don't have syphilis. Positive results are given as a ratio in titers. This tells your healthcare provider the amount of antibodies in your blood. If you have a history of syphilis and your RPR test is negative or nonreactive, it is likely that you no longer have syphilis.

Subsequently, question is, why would RPR be reactive? A normal RPR blood sample shows no antibodies typically produced during an infection. One reason for a false positive is the presence of another disease that produces antibodies similar to the ones produced during a syphilis infection. A few of the conditions that can cause a false positive include the following: HIV.

Also asked, what does a reactive RPR mean?

RPR test: Rapid plasma reagin, a blood test for syphilis that looks for an antibody that is present in the bloodstream when a patient has syphilis. A negative (nonreactive) RPR is compatible with a person not having syphilis, but in the early stages of the disease, the RPR often gives false negative results.

Why is RPR nonspecific?

Reagin is not a specific antibody to Treponema pallidum, but is an IgM antibody to tissue lipids. RPR titers drop rapidly after treatment of primary or secondary syphilis, while the FTA-ABS remains reactive, irrespective of treatment. RPR is not highly specific.

28 Related Question Answers Found

Is non reactive and negative the same thing?

A non-reactive result means that no HIV antibodies were detected. Antibodies are your body's response to a virus or infection. A non-reactive test means that a person is HIV-negative. A reactive result is considered a preliminary positive, and means that HIV antibodies were found.

Can you get syphilis without being sexually active?

Syphilis is a sexually transmitted infection (STI) caused by the bacterium Treponema pallidum. When it's not active, you don't have symptoms, even though you still have syphilis. But even when you don't have symptoms, you can pass syphilis to others. You don't have to have sexual intercourse to get syphilis.

What are the 4 stages of syphilis?

Syphilis is a sexually transmitted infection (STI). There are four stages of the disease: primary, secondary, latent, and tertiary (also known as neurosyphilis). Primary syphilis is the first stage of the disease. It causes one or more small, painless sores in or around the genitals, anus, or mouth.

How accurate is a syphilis blood test?

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With blood testing, syphilis can be detected as early as 1 to 2 weeks after exposure. The highest accuracy can be expected within about three months, with false positive results possible any time within the initial 90 days after infection.

How long can syphilis lay dormant?


After the initial infection, the syphilis bacteria can lie dormant in your body for decades before becoming active again. Early syphilis can be cured, sometimes with a single injection of penicillin. Without treatment, syphilis can severely damage your heart, brain or other organs, and can be life-threatening.

What is the first sign of syphilis?

Symptoms for the first stage normally appear 10 days to 3 months after you're exposed to syphilis. You might notice that the lymph nodes near your groin are enlarged. Typically, the first visible sign of syphilis is a small, painless sore (doctors call it a “chancre”) on the skin (you may develop several sores).

How can you test for syphilis at home?

You can get tested for syphilis whether or not you have any sores or symptoms. Usually, your nurse or doctor will take a quick blood sample to test you for syphilis. If you have open sores, they may gently take a sample of fluid from the sore with a swab and test it.

What is the confirmatory test for syphilis?

Tests to confirm syphilis
Tests used to confirm a syphilis infection include: Enzyme immunoassay (EIA) test. This blood test checks for syphilis antibodies. A positive EIA test should be confirmed with either the VDRL or RPR tests.

Is RPR positive for life?

Nontreponemal Antibody Tests: VDRL and RPR. These antibodies remain positive for life even after treatment. Same as primary stage. The CSF FTA-ABS is less specific than VDRL, but the test is highly sensitive; can be used to exclude neurosyphilis.

What are the signs of syphilis in a woman?


These syphilis symptoms may come and go for up to 2 years. They include body rashes that last 2 – 6 weeks — often on the palms of your hands and the soles of your feet. There are lots of other symptoms, including mild fever, fatigue, sore throat, hair loss, weight loss, swollen glands, headache, and muscle pains.

Is RPR test reliable?

Interpreting RPR results and accuracy
A normal test result typically reveals that the blood does not contain any antibodies that are reactive to syphilis. It is best to do the RPR test in the middle stages of a syphilis infection — after the body has built up an antibody defense, but before any treatment takes place.

What is the STD syphilis?

Syphilis is a sexually transmitted disease (STD) caused by an infection with bacteria known as Treponema pallidum. Like other STDs, syphilis can be spread by any type of sexual contact. Syphilis can also be spread from an infected mother to the fetus during pregnancy or to the baby at the time of birth.

Is RPR always positive after treatment?

It is compatible with cure if there was a ≥4-fold decrease in RPR or VDRL titer after treatment and the sustained serofast titer is ≤1:16. RPR or VDRL results may be negative in primary syphilis (in up to 25% of cases) but in secondary syphilis are virtually always positive and are typically >1:8.

What does syphilis do to the brain?

Syphilis can invade the nervous system at any stage of infection, and causes a wide range of symptoms, including headache, altered behavior, difficulty coordinating muscle movements, paralysis, sensory deficits, and dementia. This invasion of the nervous system is called “neurosyphilis.

Can syphilis be misdiagnosed?


Yes, syphilis is a curable disease. It is usually treated with penicillin. However syphilis can be misdiagnosed, especially if a person is in the secondary stage and is suffering what appears to be flu symptoms.

What does FTA ABS reactive mean?

The fluorescent treponemal antibody absorption (FTA-ABS) test is a blood test that checks for the presence of antibodies to Treponema pallidum bacteria. These bacteria cause syphilis. Syphilis s a sexually transmitted infection (STI) that's spread through direct contact with syphilitic sores.

How long is RPR positive after treatment?

The VDRL and RPR, respectively, are reactive in 78 percent and 86 percent of patients with primary syphilis. 8 They become positive within approximately four to six weeks after infection or one to three weeks after the appearance of the primary lesion.