What does Leukoreduced blood mean?

Asked By: Abad Mazu | Last Updated: 5th March, 2020
Category: medical health cancer
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Leukoreduction: A process used to filter and remove white blood cells from whole blood before transfusion. The reason why white blood cells (leukocytes) are removed from blood is because they provide no benefit to the recipient but can carry bacteria and viruses to the recipient.

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Also, what does it mean when blood is irradiated?

Irradiated blood is blood that has been treated with radiation (by x-rays or other forms of radioactivity) to prevent Transfusion- Associated Graft-versus-Host Disease (TA-GvHD).

Additionally, when can you buy Leukoreduced blood? Leukoreduced and irradiated erythrocytes should be used when transfusing select patients who are immunocompromised to reduce the risk of transfusion-associated graft-versus-host disease and febrile nonhemolytic transfusion reaction.

Also question is, is all blood Leukoreduced?

As of 2008, most developed nations have adopted universal leukoreduction of transfusions (defined as the routine application of this blood-processing step to all units of whole blood, red blood cells, and platelets prior to storage) with the notable exception of the United States.

How is Leukoreduction done?

A key step in the process is to pass the blood through a specialized filter that removes white blood cells or leukocytes, and we call this leukoreduction. During our manufacturing process, blood is suspended so that it flows through the leukoreduction filter.

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Who requires irradiated blood?

Immunocompromised patients such as
  • Infants (particularly premature) up to 4, 6, or 12 months depending on institutional policy.
  • Intrauterine transfusion* and/or neonatal exchange transfusion recipients.
  • Congenital immunodeficiency disorders of cellular immunity (i.e., SCID, DiGeorge)*

What is Leucodepleted blood used for?

Leucodepletion is a technical term for the removal of leucocytes (white blood cells) from blood components using special filters.

Why do I need irradiated blood?

Why does the blood need to be irradiated? Preventing any remaining white blood cells in donor blood from dividing helps to prevent a rare complication of blood transfusion called 'transfusion-associated graft-versus-host disease' (TA-GvHD).

Do chemo patients need irradiated blood?

Blood Irradiation
To prevent this, some centers irradiate (treat with radiation) blood components for patients receiving intensive chemotherapy, undergoing stem cell transplant or who are considered to have impaired immune system. Irradiation prevents white cells from attacking.

What is the difference between radiated and irradiated blood?


Irradiated or non-irradiated transfusions have many risks involved including elevated potassium levels and graft versus host disease (TA-GVHD). Irradiated blood is able to destroy the leukocytes responsible for TA-GVHD, but it adversely causes elevated extracellular potassium due to hemolysis of the RBC's.

What is washed packed red blood cells?

Washed red blood cells are red blood cells which have had most of the plasma, platelets and white blood cells removed and replaced with saline or another type of preservation solution. The usual cause of these allergic reactions is proteins in the donor plasma.

How long does it take to irradiate blood?

It has no clinically significant effect on red cell pH, glucose, 2,3 DPG levels or ATP. Packs irradiated within 14 days of collection expire 28 days after collection. Packs irradiated more than 14 days after collection expire either 5 days after irradiation OR at original expiry of pack, whichever comes first.

What is TA GVHD?

Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of blood transfusion, in which the immunologically competent donor T lymphocytes mount an immune response against the recipient's lymphoid tissue. This can result in transfusion associated graft-versus-host disease.

What is leukapheresis procedure?


Leukapheresis is a laboratory procedure in which white blood cells are separated from a sample of blood. It is a specific type of apheresis, the more general term for separating out one particular constituent of blood and returning the remainder to the circulation.

What is LRBC?

LRBC. Abbreviation for “Leukocyte-reduced red blood cells.”

What is a white blood cell transfusion?

White Blood Cell Transfusions
White blood cells are called granulocytes. If you have serious, life-threatening infections that do not respond to appropriate antibiotics, you may have low levels of granulocytes. In some cases, a transfusion of granulocytes is used for a short time to help you fight infections.

What is extracorporeal volume?

A procedure in which blood is taken from a patient's circulation to have a process applied to it before it is returned to the circulation. All of the apparatus carrying the blood outside the body is termed the extracorporeal circuit.

What is cryoprecipitate used for?

What Is Cryo in Blood? Cryo is used to prevent or control bleeding in people whose own blood does not clot properly. This includes patients with serious but rare hereditary conditions such as Hemophilia A (who lack factor VIII) and von Willebrand disease (who lack von Willebrand factor).

How do you wash platelets?


Washed Platelets
Plasma can be removed from platelets by washing. This will reduce the risk of a transfusion reaction in key patient populations (see below). Washing reduces the platelet count by approximately 10-15%. Coordination with the Blood Bank is required.

Do packed red blood cells contain platelets?

Red blood cells (RBCs), also known as packed red blood cells (pRBCs), are prepared from whole blood by removing plasma. All RBC transfusions must be ABO compatible with the recipient. Red blood cells do not provide viable platelets, nor do they provide clinically significant amounts of coagulation factors.

How do you clean red blood cells?

Step 1: Centrifuge the whole blood at 3000rpm (1800rcf) for 5 minutes Step 2: Remove plasma and buffy coat layer. Step 3: Resuspend the red cells in normal saline (0.9% NaCl) with approximately 2 times the volume of the red cells, and invert the tube to mix.