What does insulin independent mean?
Besides, which organs are insulin independent?
Sites of Insulin Action and Manifestations of Insulin Resistance
- Muscle. Glucose uptake into muscle is essentially insulin dependent via GLUT 4, and muscle accounts for about 60–70% of whole-body insulin mediated uptake.
- Adipose Tissue.
- Endothelium and Vasculature.
Also, what is the difference between insulin dependent and non insulin dependent diabetes? Without insulin, cells cannot absorb sugar (glucose), which they need to produce energy. Type 2 diabetes (formerly called adult-onset or non–insulin-dependent diabetes) can develop at any age. This is called insulin resistance. As type 2 diabetes gets worse, the pancreas may make less and less insulin.
Likewise, can glucose enter cells without insulin?
Without insulin, cells are unable to use glucose as fuel and they will start malfunctioning. Extra glucose that is not used by the cells will be converted and stored as fat so it can be used to provide energy when glucose levels are too low.
Why is glut4 insulin dependent?
GLUT4 is the insulin-regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac). At the cell surface, GLUT4 permits the facilitated diffusion of circulating glucose down its concentration gradient into muscle and fat cells.