What are the indications for filgrastim?

Asked By: Jaspal Huon | Last Updated: 1st April, 2020
Category: medical health cancer
4.8/5 (36 Views . 21 Votes)
NEUPOGEN (filgrastim) is approved for 5 indications in the following patient populations:
  • Chemotherapy-induced Febrile Neutropenia.
  • Acute Myeloid Leukemia.
  • Cancer Patients Receiving Bone Marrow Transplant.
  • Peripheral Blood Progenitor Cell Collection and Engraftment.
  • Severe Chronic Neutropenia.

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Herein, when should Neupogen be given?

The recommended dosage of NEUPOGEN for the mobilization of autologous peripheral blood progenitor cells (PBPC) is 10 mcg/kg/day given by subcutaneous injection. Administer NEUPOGEN for at least 4 days before the first leukapheresis procedure and continue until the last leukapheresis.

Additionally, what is Filgrastim used to treat? Filgrastim injection is used to treat neutropenia (low white blood cells) that is caused by cancer medicines. It is a synthetic (man-made) form of a substance that is naturally produced in your body called a colony stimulating factor. Filgrastim helps the bone marrow to make new white blood cells.

In this way, when should filgrastim be given?

The manufacturer recommends that the first dose of filgrastim be given no sooner than 24 hours after chemotherapy. Your doctor will discontinue therapy with filgrastim when your white blood cell count has reached acceptable levels.

What type of drug is filgrastim?

colony-stimulating factors

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How long does it take filgrastim to work?

If you are using filgrastim injection products to decrease the risk of infection, decrease the time with fever, or increase the number of white blood cells during chemotherapy, you will receive your first dose of the medication at least 24 hours after you receive a dose of chemotherapy, and will continue to receive the

How long does Neupogen stay in system?

Your doctor will tell you when to begin your treatment and when to stop. are only required to use NEUPOGEN for short periods of time until the number of infection-fighting neutrophils are restored (usually up to 14 days, but can be longer). Stem cell donors would normally receive NEUPOGEN treatment for 4 to 7 days.

How much does Neupogen cost?

The cost for Neupogen injectable solution (300 mcg/0.5 mL) is around $358 for a supply of 0.5 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

Does Filgrastim increase WBC?

About: Filgrastim (Neupogen®, G-CSF)
Granulocyte colony-stimulating factor (G-CSF) is a protein naturally produced by the body to increase the production of white blood cells. Filgrastim is a man-made version of G-CSF that stimulates white blood cell production, and in particular, neutrophil production.

Can Neupogen cause cancer?

Normal individuals are at risk for developing cancer, including leukaemia, lymphoma or other blood diseases throughout their lifetime. Based on limited long-term data from healthy people who have received filgrastim, no long-term risks have been found so far.

How long do the effects of Neupogen last?

Neulasta is a one-time injection given after each cycle that provides 14 days of coverage. Neupogen can be given daily for up to 14 days, depending on the type of chemotherapy. The most common side effect experienced by patients is bone pain.

Does Neupogen make you tired?

tired feeling, skin rash, nosebleeds, or. injection site reactions (redness, swelling, itching, lumps or bruising).

Where do you inject filgrastim?

Choose an injection site from one of the following areas (see Figure 1).
  • The outer area of your upper arms.
  • Your abdomen (belly), except for the 2-inch area around your belly button.
  • The middle of the front of your thighs.
  • The upper areas of your buttocks.

How can you increase your white cell count?

Plan your meals to include these 15 powerful immune system boosters.
  1. Citrus fruits. Most people turn to vitamin C after they've caught a cold.
  2. Red bell peppers. If you think citrus fruits have the most vitamin C of any fruit or vegetable, think again.
  3. Broccoli.
  4. Garlic.
  5. Ginger.
  6. Spinach.
  7. Yogurt.
  8. Almonds.

Is Filgrastim cytotoxic?

Febrile neutropenia (FN) is a serious and frequent complication of cytotoxic chemotherapy. Biosimilar filgrastim (Nivestim™, Hospira Inc, A Pfizer Company, Lake Forest, IL, USA) is a granulocyte-colony stimulating factor licensed for the treatment of neutropenia and FN induced by myelosuppressive chemotherapy.

How long does Grastofil stay in your system?

Discard drug if it is left at room temperature beyond this time period. For Grastofil, pre-filled syringes may be stored at room temperature for one single period of up to 15 days. Discard drug if it is left at room temperature beyond this time period.

How can I increase my white blood cells during chemo?

CSFs help your body make more white blood cells. This lowers your risk for febrile neutropenia. CSFs include Neupogen (filgrastim), Neulasta (pegfilgrastim), and Leukine and Prokine (sargramostim). They are usually given as shots 24 hours after a chemotherapy treatment.

Can filgrastim be frozen?

If NEUPOGEN® is accidentally frozen, allow it to thaw in the refrigerator before giving the next dose. However, if it is frozen a second time, do not use it and contact your doctor or nurse for further instructions. NEUPOGEN® can be left out at room temperature for up to 24 hours.

What is Grastofil?

GRASTOFIL® • Filgrastim (fill-GRASS-tim) is a drug that helps your bone marrow make new white. blood cells. White blood cells protect your body by fighting bacteria (germs) that cause infection. Filgrastim is a clear liquid that is injected under your skin or into a vein.

What medications can increase WBC?

Drugs that may increase WBC counts include:
  • Beta adrenergic agonists (for example, albuterol)
  • Corticosteroids.
  • Epinephrine.
  • Granulocyte colony stimulating factor.
  • Heparin.
  • Lithium.

What is GCSF used for?

Granulocyte-colony stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.