What are the central Chemoreceptors normally most sensitive to?

Asked By: Felicidad Beuck | Last Updated: 1st March, 2020
Category: medical health heart and cardiovascular diseases
4.9/5 (194 Views . 15 Votes)
Central chemoreceptors are sensitive to increases in arterial carbon dioxide and decreases in arterial pH.

Click to see full answer


Regarding this, what are the peripheral chemoreceptors normally most sensitive to?

The peripheral chemoreceptors are directly sensitive to the partial pressures of arterial oxygen and carbon dioxide as well as Blood pH; however, the mechanisms by which the concentrations of these molecules is connected to chemoreceptor activity is not well-understood.

Likewise, which chemical is most likely to directly affect central Chemoreceptors? Central chemoreceptors in the pons (locus ceruleus) and medulla (raphe nuclei, ventrolateral nuclei, and nucleus of tractus solitarius) are influenced primarily by changes in carbon dioxide tension (Pco2) concentrations.

Also, what do Central chemoreceptors respond to?

central chemoreceptors: Located within the medulla, they are sensitive to the pH of their environment. peripheral chemoreceptors: The aoritic and carotid bodies, which act principally to detect variation of the oxygen concentration in the arterial blood, also monitor arterial carbon dioxide and pH.

Which situation causes central chemoreceptors to increase the respiratory rate?

Central respiratory chemoreception is the mechanism by which an increase in brain PCO2 stimulates breathing. The term also refers to the respiratory stimulation caused by metabolic acidosis (blood acidification at normal levels of CO2).

36 Related Question Answers Found

What stimulates hypoxic drive?

When those carbon dioxide levels are high a signal is sent to speed up the drive to breathe to blow off the excess carbon dioxide. They will send a signal to breathe when the partial pressure of oxygen begins to fall. This is referred to as the hypoxic drive but this drive has a much more minor role in breathing.

What happens when Chemoreceptors are stimulated?

If respiratory activity increases in response to the chemoreceptor reflex, then increased sympathetic activity stimulates both the heart and vasculature to increase arterial pressure. A decrease in carotid body blood flow as can occur during circulatory shock also increases receptor firing.

What are Chemoreceptors sensitive to?

Chemoreceptors in the carotid bodies and aortic arch are sensitive to changes in arterial carbon dioxide, oxygen, and pH. The carotid bodies are generally more important in mediating this response and provide the principal mechanism by which mammals sense lowered levels of oxygen.

What do Chemoreceptors detect?

Particular chemoreceptors, called ASICs, detect the levels of carbon dioxide in the blood. To do this, they monitor the concentration of hydrogen ions in the blood, which decrease the pH of the blood.

What are the major effects of peripheral Chemoreceptor stimulation?


The vascular effects of peripheral chemoreceptor stimulation include coronary vasodilation and vasoconstriction in skeletal muscle and the splanchnic area.

What is the Chemoreceptor reflex?

In human nervous system: Reflex pathways. Overall, the chemoreceptor reflex regulates respiration, cardiac output, and regional blood flow, ensuring that proper amounts of oxygen are delivered to the brain and heart.

Why do we hyperventilate?

You breathe in oxygen and breathe out carbon dioxide. Excessive breathing creates a low level of carbon dioxide in your blood. This causes many of the symptoms of hyperventilation. You may hyperventilate from an emotional cause such as during a panic attack.

What is the difference between baroreceptors and chemoreceptors?

Baroreceptors are stretch receptors of afferent nerves located in the carotid sinuses and arch of the aorta. Peripheral chemoreceptors are located in the aorta and carotid arteries. They monitor changes in blood O2 and pH and mediate immediate responses in breathing, blood pressure and heart rate to those changes.

Where is the central Chemoreceptor located?

Central chemoreceptors of the central nervous system, located on the ventrolateral medullary surface in the vicinity of the exit of the 9th and 10th cranial nerves, are sensitive to the pH of their environment.

What will occur if central Chemoreceptors detect an increase in co2?


Central chemoreceptors are sensitive to increases in arterial carbon dioxide and decreases in arterial pH. Hypercarbia elicits a rapid and vigorous increase in minute ventilation (see Chapter 29). Volatile anesthetics, opioids, and nitrous oxide attenuate this response in a dose-dependent fashion.

Does the carbon dioxide stimulate the central Chemoreceptors directly?

So, in the CSF CO2 and water reacts to form H2CO3, which again reacts to form HCO3- and H+ (protons). These protons can not cross the blood brain barrier, and therefore build up in the extracellular fluid --> stimulating the chemoreceptors.

What directly stimulates the central Chemoreceptors?

Stimulation causes the diaphragm to contract (increasing volume and decreasing pressure), thus causing inspiration. - Yes, hydrogen ions (H+) stimulate the central chemoreceptors. CO2 is converted to H+ in the extracellular fluid of the brain.

What controls the rate and depth of respiration?

The respiratory centre in the medulla and pons of the brainstem controls the rate and depth of respiration, (the respiratory rhythm), through various inputs. The ventral respiratory group controls voluntary forced exhalation and acts to increase the force of inhalation.

What does hypercapnia do to the central nervous system?

Acute hypercapnia increases sympathetic nervous system discharge. As a result, plasma levels of epinephrine and norepinephrine rise, leading to increased myocardial contractility and cardiac output but also increased risk for cardiac arrhythmias.

Where is the respiratory center located?


The respiratory center is located in the medulla oblongata and pons, in the brainstem. The respiratory center is made up of three major respiratory groups of neurons, two in the medulla and one in the pons.

Can water cross blood brain barrier?

The molecular pathways by which water molecules cross the blood brain barrier are not well-understood, although the discovery of Aquaporin 4 (AQP4) in the brain improved the understanding of some of these transport processes, particularly under pathological conditions.

What happens if there is an increase in carbon dioxide in the blood?

So CO2 in the bloodstream lowers the blood pH. When CO2 levels become excessive, a condition known as acidosis occurs. Breathing rate and breathing volume increase, the blood pressure increases, the heart rate increases, and kidney bicarbonate production ( in order to buffer the effects of blood acidosis), occur.