Is cytarabine a chemo drug?

Asked By: Elmahdi Heinmoller | Last Updated: 24th June, 2020
Category: medical health cancer
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Cytarabine. Cytarabine, also known as cytosine arabinoside (ara-C), is a chemotherapy medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML), and non-Hodgkin's lymphoma. Cytarabine is in the antimetabolite and nucleoside analog families of medication.

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Similarly, what kind of drug is cytarabine?

antimetabolites

Subsequently, question is, how long does cytarabine take to work? This can put you at risk for infection, anemia and/or bleeding. Nadir: White blood cells: 7-10 days, platelets: 12-15 days. Nausea and vomiting. Mouth sores (usually occur 7-10 days after therapy).

In this regard, what is cytarabine used for?

Cytarabine is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Cytarabine is used to treat certain types of leukemia (blood cancers). Cytarabine is also used to treat leukemia associated with meningitis.

Does cytarabine cause hair loss?

It is also FDA approved for use with other drugs to treat acute myeloid leukemia, acute lymphoblastic leukemia and chronic myeloid leukemia. This medicine may cause a temporary loss of hair in some people. After treatment with cytarabine has ended, normal hair growth should return.

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How much does cytarabine cost?

The cost for cytarabine injectable solution (20 mg/mL) is around $22 for a supply of 25 milliliters, depending on the pharmacy you visit.

Injectable Solution.
Quantity Per unit Price
25 milliliters $0.90 – $1.43 $22.39 – $35.75
50 milliliters $0.53 – $0.99 $26.30 – $49.40

Which phase is affected by cytarabine?

Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected.

How often is cytarabine given?

In the induction therapy of acute non-lymphocytic leukemia, the usual cytarabine dose in combination with other anticancer drugs is 100 mg/m2/day by continuous IV infusion (days 1 to 7) or 100 mg/m2 IV every 12 hours (days 1 to 7).

Does cytarabine cross the blood brain barrier?

Cytarabine crosses the blood brain barrier to a limited extent and is thought to cross the placental barrier. It is not known if cytarabine is distributed into milk. Cerebrospinal fluid levels of cytarabine are low in comparison to plasma levels after single intravenous injection.

What is cytarabine made from?

Cytarabine is isolated from the mushroom Xerocomus nigromaculatus of unknown palatability. Cytarabine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute myelogenous leukemia and meningeal leukemia.

How does cytarabine affect the skin?

Cytarabine may affect your skin. Cytarabine can cause a rash, which may be itchy. It may also cause your skin to become red or blistered. Always tell your doctor or nurse about any skin changes.

What is cytarabine syndrome?

Cytarabine syndrome is a rare clinical condition characterized by fever, malaise, myalgia, arthralgia, and/or rash that occurs after receipt of cytarabine. Our patient developed fever, malaise, and diffuse body pain shortly following cytarabine initiation despite receiving prophylactic dexamethasone.

Does cytarabine cause fever?

The Cytarabine (Ara-C) Syndrome: A cytarabine syndrome has been described by Castleberry. It is characterized by fever, myalgia, bone pain, occasionally chest pain, maculopapular rash, conjunctivitis, and malaise. It usually occurs 6 to 12 hours following drug administration.

How does cytarabine prevent replication?

Cytarabine is metabolized to an active drug that inhibits DNA synthesis. Cytarabine is an anti-metabolite synthetic nucleoside analogue. Cytarabine A inhibits DNA polymerase in mitotically active cells and produces topoisomerase dysfunction and prevents DNA repair.

How does Cytoxan work?

It is a chemotherapy drug that works by slowing or stopping cell growth. Cyclophosphamide also works by decreasing your immune system's response to various diseases. It is used to treat a certain type of kidney disease in children after other treatments have not worked.

Where does asparaginase come from?

asparaginase made from a type of bacteria called Escherichia coli (also known by its brand Spectrila) asparaginase made from the Erwinia chrysanthemia bacteria (Erwinase)

What are the side effects of etoposide?

Nausea, vomiting, diarrhea, dizziness, tiredness, weakness, changes in taste, loss of appetite, and pain/redness at the injection site may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting.

Can cytarabine be given Intrathecally?

Cytarabine Injection is not active orally. Cytarabine Injection may be given by intravenous infusion or injection, subcutaneously, or intrathecally (preservative free preparation only).

Where is doxorubicin from?

Doxorubicin is classified as an antitumor antibiotic. Antitumor antibiotics are made from natural products produced by species of the soil fungus Streptomyces. These drugs act during multiple phases of the cell cycle and are considered cell-cycle specific.

Is cytarabine a vesicant or irritant?

Cyclophosphamide (Cytoxan) (irritant or neutral, depending on reference) Cytarabine (Ara-C) (irritant or neutral, depending on reference) Gemcitabine (Gemzar) (irritant or neutral, depending on reference) Ifosfamide (Ifex) (irritant or neutral, depending on reference)

Is cytarabine cell cycle specific?

Chemotherapy drugs that affects cells only when they are dividing are called cell-cycle specific. Cytarabine belongs to the category of chemotherapy called antimetabolites. Antimetabolites are very similar to normal substances within the cell.