How is intracranial pressure maintained?
Simply so, how is intracranial pressure regulated?
According to the anatomists Monro and Kellie, ICP is determined by three parameters; the volume of the brain, cerebral blood volume and cerebrospinal fluid (CSF) volume, where cerebral blood volume and CSF are homeostatically controlled and compensate for acute changes in ICP .
Furthermore, how does mannitol reduce intracranial pressure?
Mannitol decreases blood viscosity, CBF unchanged while CBV and ICP decrease. Mannitol also reduces ICP by reducing cerebral parenchymal cell water, total effect takes 20-30min. Eventually Mannitol enters CSF and increases ICP. Sedation decreases anxiety, fear, and response to pain, all of which increase ICP.
Effective treatments to reduce pressure include draining the fluid through a shunt via a small hole in the skull or through the spinal cord. The medications mannitol and hypertonic saline can also lower pressure. They work by removing fluids from your body.