How does vitamin K affect the clotting cascade and warfarin?
People also ask, how does warfarin affect the clotting cascade?
Tissue injury initiates the intrinsic pathway and compromises the vast majority of the coagulation cascade. Warfarin inhibits vitamin-K dependent cofactors (II, VII, IV, X) in addition to protein C and protein S. Warfarin acts across both the extrinsic and intrinsic pathways to prevent thrombus formation.
Likewise, how does vitamin K interfere with warfarin? Warfarin works against vitamin K. Specifically, warfarin reduces your liver's ability to use vitamin K to produce normally functioning forms of the blood clotting proteins. For example, if you reduce the amount of vitamin K in your diet, your INR will increase.
Hereof, how does vitamin K affect coagulation?
Major Interaction. Vitamin K is used by the body to help blood clot. Warfarin (Coumadin) is used to slow blood clotting. By helping the blood clot, vitamin K might decrease the effectiveness of warfarin (Coumadin).
What clotting factors need vitamin K?
Vitamin K serves as an essential cofactor for a carboxylase that catalyzes carboxylation of glutamic acid residues on vitamin K-dependent proteins. The key vitamin K-dependent proteins include: Coagulation proteins: factors II (prothrombin), VII, IX and X. Anticoagulation proteins: proteins C, S and Z.