Does metaplasia lead to dysplasia?

Asked By: Karamo Kaufholdt | Last Updated: 10th January, 2020
Category: medical health digestive disorders
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Metaplasia (Greek: "change in form") is the reversible replacement of one differentiated cell type with another mature differentiated cell type. Metaplasia is not synonymous with dysplasia and is not directly considered carcinogenic.

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Also asked, what is the difference between metaplasia and dysplasia?

Metaplasia (Greek: "change in form") is the transformation of one differentiated cell type to another differentiated cell type. Metaplasia is not synonymous with dysplasia, and is not considered to be an actual cancer.

Additionally, what are some causes of metaplasia? pylori infection causes intestinal metaplasia, but there is also a range of risk factors that may increase the risk of developing it.

Other factors for intestinal metaplasia may include:

  • environmental toxins, such as secondhand smoke or chemicals.
  • high salt intake.
  • alcohol consumption.
  • chronic acid reflux.

Hereof, does metaplasia lead to cancer?

Intestinal metaplasia is believed to be a precancerous lesion that may lead to gastric cancer. If you have intestinal metaplasia, then your risk of getting gastric cancer is increased six times .

What is an example of metaplasia?

Metaplasia is the conversion from one type of normal adult cell to another type of normal adult cell. An example of physiologic metaplasia is the squamous metaplasia that occurs in the uterine cervix during the menstrual cycle as the squamocolumnar junction migrates across the transformation zone (Fig. 1-13).

36 Related Question Answers Found

How serious is dysplasia?

Severe dysplasia is the most serious form of cervical dysplasia. It's not cancer, but it has the potential to become cancer. It doesn't usually cause symptoms, so it's almost always discovered during routine screening.

What does dysplasia mean in medical terms?

Medical Definition of dysplasia
1 : variation in somatotype (as in degree of ectomorphy, endomorphy, or mesomorphy) from one part of a human body to another. 2 : abnormal growth or development (as of organs or cells) broadly : abnormal anatomic structure due to such growth.

Is Barrett's esophagus metaplasia or dysplasia?

Intestinal Metaplasia Without Dysplasia: Barrett's esophagus is present, but no precancerous changes are visible in the cells of your esophageal lining. High-Grade Dysplasia: Esophagus cells display a high degree of precancerous changes, thought to be the final step before esophageal cancer.

Can metaplasia be reversed?

Metaplasia is defined as a potentially reversible change from a fully differentiated cell type to another, which implies adaptation to environmental stimuli, and that embryological commitments can be reversed or erased under certain circumstances.

What organ is most likely to show the metaplasia?


One esophagus may contain several types. The process of cell change from flat, layered squamous to tall columnar epithelium is an example of metaplasia.

Is dysplasia the same as cancer?

Cells that look abnormal under a microscope but are not cancer. Normal cells may become cancer cells. Before cancer cells form in tissues of the body, the cells go through abnormal changes called hyperplasia and dysplasia. In dysplasia, the cells look abnormal under a microscope but are not cancer.

Is metaplasia active or passive?

Metaplasia is a usually reversible change of one cell type into another upon exposure to a stimulus. All metaplasia involves changes in an epithelium, a cellular covering or lining of an organ, gland, vessel, or cavity of the body.

What is dysplasia in Barrett's esophagus?

High grade dysplasia (HGD) refers to precancerous changes in the cells of the esophagus. Gastroesophageal reflux disease (GERD) can be complicated by Barrett's esophagus (BE), a change in the normal esophageal cells to intestinal-like cells. BE cells can become abnormal or dysplastic.

Is gastric metaplasia common?

Intestinal metaplasia (IM) is recognized as a precancerous lesion for gastric cancer, increasing the risk by 6-fold. IM is highly prevalent in the general population, being detected in nearly 1 of every 4 patients undergoing upper endoscopy.

What is an early sign of gastric cancer?


Early Stage Stomach Cancer Symptoms
Unexplained weight loss. Abdominal pain or vague pain just above the belly button area. Indigestion, heartburn or vomiting. Loss of or decrease in appetite.

Is Anaplasia reversible?

Practice of Toxicologic Pathology
Metaplasia is the reversible substitution of one type of fully differentiated cell for another within a given tissue, and is seen most commonly in epithelial tissues.

Is gastric cancer curable?

Many cases of stomach cancer can't be completely cured, but it's still possible to relieve symptoms and improve quality of life using chemotherapy and in some cases radiotherapy and surgery. If operable, surgery can cure stomach cancer as long as all of the cancerous tissue can be removed.

What is the meaning of squamous metaplasia?

Squamous metaplasia is a benign non-cancerous change (metaplasia) of surfacing lining cells (epithelium) to a squamous morphology.

What does precancerous mean?

Definition. Precancerous cells (also called premalignant cells) are defined as abnormal cells that could turn into cancerous cells, but which, by themselves, are not invasive.

Is squamous metaplasia dangerous?


Human papillomavirus (HPV) infection of metaplastic squamous epithelium can result in dysplasia and squamous cell cancer11. HPV is associated with nearly all cervical dysplastic and cancer tissues12,13. Other types of squamous metaplasia are rare.

How long does it take for biopsy results to come back from endoscopy?

Times vary, depending on the laboratory and the extent of testing needed. For a typical biopsy, results are often returned within 2–3 days. If the sample needs more extensive testing, results could take 7–10 days. Ask the doctor for an estimate of how long results will take.

What is chronic gastritis with intestinal metaplasia?

Chronic gastritis has a high incidence in adults, causing progressive destruction of glandular structures, favoring the development of gastric atrophy. The association of chronic gastritis with intestinal type metaplasia of gastric mucosa has a poor outcome as intestinal metaplasia is regarded as a precancerous lesion.